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Message: <blockquote data-quote="Sri_Sampath" data-source="post: 17359625" data-attributes="member: 264139">Use of corticosteroids has numerous side-effects, some of which may be severe:Neuropsychiatric: steroid psychosis,[8] and anxiety,[9] depression. Therapeutic doses may cause a feeling of inappropriate well-being ("steroid euphoria").[10] The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being energized will interfere with sleep. An extensive review is provided by Flores and Gumina.[11]Cardiovascular: Corticosteroids can cause sodium retention through a direct action on the kidney, in a manner analogous to the mineralocorticoid aldosterone. This can result in fluid retention and hypertension.Metabolic: Corticosteroids cause a movement of body fat to the face and torso, resulting respectively in "moon face" and "buffalo hump". and away from the limbs. Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, and long term therapy can cause muscle wasting[12]Endocrine: By increasing the production of glucose from amino-acid breakdown and opposing the action of insulin, corticosteroids can cause hyperglycemia,[9] insulin resistance and diabetes mellitus.[9]Skeletal: Steroid-induced osteoporosis may be a side-effect of long-term corticosteroid use. While cases of colitis have been reported, corticosteroids are therapeutically employed when the colitis has an auto-immune nature, e.g. ulcerative colitis and Crohn's disease. Use of inhaled corticosteroids among children with asthma may result in decreased height.[13]Gastro-intestinal: While the evidence for corticosteroids causing peptic ulceration is relatively poor except for high doses taken for over a month,[14] the majority of doctors as of 2010 still believe this is the case, and would consider protective prophylactic measures.[15]Eyes: chronic use may predispose to cataract and retinopathy.Vulnerability to infection: By suppressing immune reactions (which is one of the main reasons for their use in allergies), steroids may cause infections to flare up, notably candidiasis.[16]The most common cause of Cushing's syndrome is exogenous administration of glucocorticoids prescribed by a health care practitioner to treat other diseases (called iatrogenic Cushing's syndrome). This can be an effect of corticosteroid treatment of a variety of disorders such as asthma and rheumatoid arthritis, or in immunosuppression after an organ transplant. Administration of synthetic ACTH is also possible, but ACTH is less often prescribed due to cost and lesser utility. Although rare, Cushing's syndrome can also be due to the use of medroxyprogesterone acetate.[12][13] In this form of Cushing's, the adrenal glands atrophy due to lack of stimulation by ACTH, since glucocorticoids downregulate production of ACTH. Cushing's syndrome in childhood usually results from use of glucocorticoid medication.[14]<img src="http://almost.thedoctorschannel.com/wp-content/uploads/2014/03/tumblr_lyq13yRBiM1qkqueuo1_500.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /><img src="http://www.hormone.org/~/media/Hormone/Images/Questions%20and%20Answers/Pituitary/Cushings.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /><img src="http://pituitary.ucla.edu/images/site/CD3.3.jpg" alt="" class="fr-fic fr-dii fr-draggable " style="" /><img src="http://c1-preview.prosites.com/19225/wy/images/Male%20abd%20after-AP.JPG" alt="" class="fr-fic fr-dii fr-draggable " style="" />This should not be confused with ectopic Cushing syndrome .[4]</blockquote>

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