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<blockquote data-quote="imhotep" data-source="post: 28359706" data-attributes="member: 562115"><p>Dr David Sinclair is very well known in this field. The Harvard team has been working for quite some time. </p><p>He is the author of <strong>"Lifespan: Why We Age―and Why We Don't Have To"</strong></p><p>He believes old age is a disease and can be treated one day. His team is essentially looking for the polish to get the cell to read the genome correctly again.</p><p>Their work of turning on "Yamanaka Factors" - OSKM led to these developments. They showed that trio of Yamanaka factors (OSK) effectively made cells younger without causing them to lose their identity (i.e., turning back into induced pluripotent stem cells) or fueling tumor growth even after a year of continuous treatment of the entire body of a mouse. </p><p></p><p>PS: For non-medical general audience there are several books by Dr Nessa Carey which nicely describes the World of Epigenetics. Read them if you can.</p><p></p><p><strong>The Epigenetics Revolution </strong>- <em>How Modern Biology Is Rewriting Our Understanding of Genetics</em>, <em>Disease, and Inheritance</em></p><p><strong>Junk DNA</strong> - <em>A Journey Through the Dark Matter of the Genome</em></p><p><strong>Hacking the Code of Life - </strong><em> How gene editing will rewrite our futures</em></p></blockquote><p></p>
[QUOTE="imhotep, post: 28359706, member: 562115"] Dr David Sinclair is very well known in this field. The Harvard team has been working for quite some time. He is the author of [B]"Lifespan: Why We Age―and Why We Don't Have To"[/B] He believes old age is a disease and can be treated one day. His team is essentially looking for the polish to get the cell to read the genome correctly again. Their work of turning on "Yamanaka Factors" - OSKM led to these developments. They showed that trio of Yamanaka factors (OSK) effectively made cells younger without causing them to lose their identity (i.e., turning back into induced pluripotent stem cells) or fueling tumor growth even after a year of continuous treatment of the entire body of a mouse. PS: For non-medical general audience there are several books by Dr Nessa Carey which nicely describes the World of Epigenetics. Read them if you can. [B]The Epigenetics Revolution [/B]- [I]How Modern Biology Is Rewriting Our Understanding of Genetics[/I], [I]Disease, and Inheritance[/I] [B]Junk DNA[/B] - [I]A Journey Through the Dark Matter of the Genome[/I] [B]Hacking the Code of Life - [/B][I] How gene editing will rewrite our futures[/I] [/QUOTE]
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