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Message: <blockquote data-quote="imhotep" data-source="post: 26105455" data-attributes="member: 562115">The Oxford vaccine is an adenovirus vector vaccine. The adenovirus vector used has an inserted gene that encodes the full-length SARS-CoV-2 spike protein.The idea to use an adenovirus as a vector to deliver the vaccine is simply because the virus can enter the human cells quite easily by attaching with the host receptors and then release their genome in to the human cells. So this particular vaccine, once inside the human cells will start producing the spike protein, because it's been modified to do so.The produced spike protein then acts as an antigen to prime the body immune system to recognize SARS-CoV-2 if it infects the body at a later date.But there's a small snag in the above scenario. There are several adenoviruses that affect us, and many people have adenovirus-specific antibodies that could bind and neutralize these vectors. So, when a person is given a viral-vector vaccine, as well as generating an immune response against the coronavirus’s spike protein, the immune system will also mount a response against the viral vector itself.Hence the research scientists at Oxford used a clever approach. They used an adenovirus of chimpanzee origin that does not normally infect humans. Hence we would not likely have pre-existing antibodies to the adenovirus vector used. They also changed the adenovirus itself by the deletion of TWO genes. One of the genes deleted is the one regulating the virus replication - this makes sure that virus cannot create an infection in human cells, and the second deletion was to get the space to insert the gene that will code for the SARS-CoV-2 spike protein.OTOH Gamelaya (Russian vaccine developer) used another approach. They used their already existing Ebola vaccine platform. They used used TWO different human adenovirus vectors – Ad26 and Ad5 (out of the 50 odd that affect humans) – for its two vaccine doses. This hybrid vaccine, with two different vectors for prime and booster vaccinations, is less likely to have one jab generate an immune response against the viral vector that then interferes with the other.Don't get fooled by the crap on the Internet saying that mRNA or an adenovirus will alter your DNA. Total bull!@#$ and you will not turn into a Chimpanzee.Our cell machinery does have extended capabilities, that goes beyond manufacturing of human proteins. What happens when we get invaded by a virus? The virus injects it's genetic material, resulting in pieces of mRNA encoding viral proteins being sent to our protein-making machinery. This enables the virus to assemble new viral particles and spread. But that doesn't alter your DNA. Otherwise everytime you fall sick, your DNA will get altered. <img src="/styles/default/xenforo/smilies/default/oo.gif"  class="smilie" loading="lazy" alt=":oo:" title="Oo    :oo:" data-shortname=":oo:" /> It's exactly the same with the vaccine.  As I have mentioned before several adenovirus based vaccines (HIV, Ebola, TB) and several mRNA vaccines (rabies, influenza, cytomegalovirus, and Zika) have been used on humans before. More than 300,000 Zika vaccines has been given in Congo alone.</blockquote>

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