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Message: <blockquote data-quote="imhotep" data-source="post: 30745466" data-attributes="member: 562115">Recently, the Karolinska Institutet in Stockholm carried out a groundbreaking genome-wide association study (GWAS) focused on long COVID using HGI data. This extensive study analyzed information from 24 research projects conducted in 16 different countries, involving 6,450 patients diagnosed with long COVID and 1,093,995 control subjects. As a result of this study, they identified the first genome-wide significant association related to long COVID at the FOXP4 locus. Notably, FOXP4 was found to be associated not only with the severity of new crown pneumonia but also with lung function and cancer, implying that lung dysfunction and the severity of new crown pneumonia play broader roles in the pathophysiology of long COVID.<h2>FOXP4 Locus Are Associated with Long COVID</h2>The link between the FOXP4 locus and long COVID has been established. Fatigue, shortness of breath, and cognitive issues such as memory and concentration problems are the prevalent symptoms of this condition. A comprehensive GWAS meta-analysis revealed a significant genetic association with long COVID in the chromosomal region 6, located upstream of the FOXP4 gene. Specifically, the presence of the rs9361706-C allele was found to be associated with a 1.63-fold higher risk of developing long COVID.</blockquote>

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