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<blockquote data-quote="athula.j" data-source="post: 20797153" data-attributes="member: 239395"><p>Aetiology[1][2] </p><p>When galactorrhoea is accompanied by amenorrhoea, it is usually caused by hyperprolactinaemia.</p><p></p><p>Physiological</p><p>Pregnancy and post-lactation: women may lactate from the second trimester, and may continue to produce milk up to two years after stopping breast-feeding.</p><p>Fluctuating hormone levels: puberty and the menopause.</p><p>Neonatal: exposure to maternal hormones in utero can produce gynaecomastia and galactorrhoea in the newborn (sometimes known as 'witch's milk'); no action is required and it will subside rapidly and spontaneously.</p><p>Nipple stimulation or suckling.</p><p>Non-physiological causes of hyperprolactinaemia</p><p>Idiopathic hyperprolactinaemia (40% of cases of hyperprolactinaemia).</p><p>Prolactinomas (PRL levels are usually very high in this case as the tumour causes hypersecretion of PRL).</p><p>Other causes of hypersecretion of PRL:</p><p>Addison's disease.</p><p>Acromegaly.</p><p>Cushing's disease.</p><p>Metastatic tumours.</p><p>Infections such as tuberculosis.</p><p>Sarcoidosis.</p><p>Histiocytosis.</p><p>Drugs (see 'Drugs that raise PRL', below).</p><p>Systemic disorders:</p><p>Chronic kidney disease.</p><p>Liver failure.</p><p>Hypothyroidism.</p><p>Epileptic seizures.</p><p>Chest wall lesions or irritation:</p><p>Breast surgery.</p><p>Burns.</p><p>Herpes zoster.</p><p>Spinal cord injury.</p><p>Trauma.</p><p>Pituitary stalk infiltration or interruption, due to:</p><p>Sarcoidosis, tuberculosis, or schistosomiasis.</p><p>Multiple sclerosis.</p><p>Resection of the pituitary stalk.</p><p>Tumours: meningioma, craniopharyngioma, dysgerminoma, dermoid cyst, pineal gland tumours.</p><p>Empty sella.</p><p>Rathke's cyst.</p><p>Irradiation.</p></blockquote><p></p>
[QUOTE="athula.j, post: 20797153, member: 239395"] Aetiology[1][2] When galactorrhoea is accompanied by amenorrhoea, it is usually caused by hyperprolactinaemia. Physiological Pregnancy and post-lactation: women may lactate from the second trimester, and may continue to produce milk up to two years after stopping breast-feeding. Fluctuating hormone levels: puberty and the menopause. Neonatal: exposure to maternal hormones in utero can produce gynaecomastia and galactorrhoea in the newborn (sometimes known as 'witch's milk'); no action is required and it will subside rapidly and spontaneously. Nipple stimulation or suckling. Non-physiological causes of hyperprolactinaemia Idiopathic hyperprolactinaemia (40% of cases of hyperprolactinaemia). Prolactinomas (PRL levels are usually very high in this case as the tumour causes hypersecretion of PRL). Other causes of hypersecretion of PRL: Addison's disease. Acromegaly. Cushing's disease. Metastatic tumours. Infections such as tuberculosis. Sarcoidosis. Histiocytosis. Drugs (see 'Drugs that raise PRL', below). Systemic disorders: Chronic kidney disease. Liver failure. Hypothyroidism. Epileptic seizures. Chest wall lesions or irritation: Breast surgery. Burns. Herpes zoster. Spinal cord injury. Trauma. Pituitary stalk infiltration or interruption, due to: Sarcoidosis, tuberculosis, or schistosomiasis. Multiple sclerosis. Resection of the pituitary stalk. Tumours: meningioma, craniopharyngioma, dysgerminoma, dermoid cyst, pineal gland tumours. Empty sella. Rathke's cyst. Irradiation. [/QUOTE]
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