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Message: <blockquote data-quote="imhotep" data-source="post: 31614154" data-attributes="member: 562115">Yes...This conundrum hasn't really been properly explained. The usual explanation was that the male lifestyle factors like smoking, alcohol etc. However, later on, the theory was that because the females carry an extra copy of protective genes.The so called fully functional tumor-suppressor genes on an otherwise idle X chromosome – underlies the broader phenomenon of cancer’s partiality toward male cells. These genes are called “EXITS,” for Escape from X-Inactivation Tumor Suppressors.Male cells would need a harmful mutation in only one copy of an EXITS gene to turn cancerous while Female cells, by contrast, would need mutations in both copies.Also the TP53 gene which is the most mutated gene in human cancer, with more than half of all human cancers harbouring a genetic alteration that interferes with the function of p53 protein is more common in men than women. Only very recently that it was revealed how cancers carrying mutations in the p53 tumor-suppressor protein can hide those mutations from T cells.PS: It's interesting to note that the American Cancer Society has flagged that cancer rates are rising significantly among women under 50, with incidence rates 82% higher than their male counterparts in 2021. Many factors could be at play here including delayed childbirth, obesity, lifestyle, processed food etcEven viral infections can be more severe in males than in females. Female human NK cells have an extra copy of an X chromosome-linked gene called UTX. UTX acts as an epigenetic regulator to boost NK cell anti-viral function.</blockquote>

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