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Message: <blockquote data-quote="imhotep" data-source="post: 31208989" data-attributes="member: 562115">Nipah raises it's head in India from time to time. Mostly in Kerala. Origin of Nipah was Malaysia in 1998. It's a member of the family Paramyxoviridae, genus Henipavirus. Mortality between 40% to 70%.The viral genome consists of a non-segmented negative sense single-stranded RNA of approximately 18.2 kb long which encodes six structural proteins.Recently (last December) it was announced that a Phase-I study of a vaccine was very promising and provides hope for further testing on a Phase -II trial.Due to the structural and sequence similarities between the NiV and Hendra virus (HeV) attachment G glycoproteins, and the extensive extant evidence of the ability of a recombinant soluble glycoprotein G (HeV-sG) to provide heterologous cross-protective immunity when used as vaccine HeV-sG-V.The immune response to HeV-sG-V was dose-dependent; a single administration was not sufficiently immunogenic, whereas two administrations were immunogenic, with the highest response rates observed among vaccinees that received two administrations of the 100 μg HeV-sG-V 28 days apart.</blockquote>

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