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UCI develops a test that detects specific SARS-CoV-2 variants with 100% accuracy
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<blockquote data-quote="imhotep" data-source="post: 28041093" data-attributes="member: 562115"><p>University of California, Irvine researchers have developed a COVID-19 test that detects and identifies specific SARS-CoV-2 variants with 100% accuracy.</p><p>REVEALR (RNA-encoded viral nucleic acid analytic reporter), a rapid and highly sensitive DNAzyme-based detection system, functions with perfect accuracy and the assay, which is programmable and amenable to multiplexing, offers an important new approach to personalized diagnostics.</p><p></p><p>"The COVID-19 pandemic has created an urgent need for individualized diagnostic tools that can recognize the presence of the virus as well as the particular strain. Identifying and triaging patients infected with variants that increase viral transmissibility and reduce vaccine protection is critical to controlling spread of the disease. Revealr goes beyond simple COVID detection methods, such as the commonly used antigen kit, to identify the precise SARS-CoV-2 strain infecting a patient."</p><p></p><p>John Chaput - UCI professor of pharmaceutical sciences"</p><p></p><p>Although Revealr was developed as a COVID detection assay, the next step is to expand to other respiratory tract infections that share symptoms with COVID-19, like influenza," Chaput said. "The ability to distinguish single-point mutation in a <strong>DNA or</strong> <strong>RNA genetic sequence makes it ideally suited for any genotyping, including cancer.</strong> Beyond human health, Revealr could find use in forensic or agricultural applications that currently rely on DNA sequencing.</p><p></p><p>They have filed a patent for Revealr genotyping.</p></blockquote><p></p>
[QUOTE="imhotep, post: 28041093, member: 562115"] University of California, Irvine researchers have developed a COVID-19 test that detects and identifies specific SARS-CoV-2 variants with 100% accuracy. REVEALR (RNA-encoded viral nucleic acid analytic reporter), a rapid and highly sensitive DNAzyme-based detection system, functions with perfect accuracy and the assay, which is programmable and amenable to multiplexing, offers an important new approach to personalized diagnostics. "The COVID-19 pandemic has created an urgent need for individualized diagnostic tools that can recognize the presence of the virus as well as the particular strain. Identifying and triaging patients infected with variants that increase viral transmissibility and reduce vaccine protection is critical to controlling spread of the disease. Revealr goes beyond simple COVID detection methods, such as the commonly used antigen kit, to identify the precise SARS-CoV-2 strain infecting a patient." John Chaput - UCI professor of pharmaceutical sciences" Although Revealr was developed as a COVID detection assay, the next step is to expand to other respiratory tract infections that share symptoms with COVID-19, like influenza," Chaput said. "The ability to distinguish single-point mutation in a [B]DNA or[/B] [B]RNA genetic sequence makes it ideally suited for any genotyping, including cancer.[/B] Beyond human health, Revealr could find use in forensic or agricultural applications that currently rely on DNA sequencing. They have filed a patent for Revealr genotyping. [/QUOTE]
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