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Message: <blockquote data-quote="imhotep" data-source="post: 27090609" data-attributes="member: 562115">A recently published breakthrough study by the Stockholm University & Umeå University of Sweden, titled "SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro" raises alarm bells.... They state that -"Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines."The finer details are in the paper itself but in simple terms, what they say is that the Spike Protein can enter into our cell nucleus, significantly inhibit the DNA damage repair which is required for V(D)J recombination in adaptive immunity.V(D)J recombination is the mechanism that occurs during certain cell phases in developing lymphocytes in early stages of T & B cell maturation. VDJ stands for variability, diversity, and joining, resulting in making each antigen receptor unique. In mammals, V(D)J recombination occurs in the primary lymphoid organs (bone marrow for B cells and thymus for T cells) Note that this study is done in-vitro (Vitro in Latin is glass) and not in-vivo ( Latin for within the living - meaning in an organism). However, possible danger in-vivo cannot be completely eliminated and is cause for concern.The study provides in-vitro evidence of the Spike protein hijacking the DNA damage repair mechanism,  and the adaptive immune machinery. It can satisfactorily explain the clinical presentations of Covid.Most importantly the study implies potential side effects of the full-length spike based vaccines. The authors suggest alternative or better strategies to design new vaccines, like using antigenic epitopes of the Spike. These can be much safer and possibly more efficacious.PS:  The full publication is available from <a href="https://www.mdpi.com/1999-4915/13/10/2056/htm" target="_blank">https://www.mdpi.com/1999-4915/13/10/2056/htm</a></blockquote>

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