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Message: <blockquote data-quote="imhotep" data-source="post: 25938089" data-attributes="member: 562115">Sorry didn't have time in the morning...As you said there are many opinions. The ex-Pfizer scientist raised concerns over pregnancy. That affects only the females and if I can get any shot, I will sure go for it. I need to stay safe first. Who knows, may be we will need repeat doses till this dreaded disease gets wiped out.Pfizer-BioNTech - mRNA basedModerna - mRNA basedAstra Zeneca (Uni of Oxford) - adenovirus basedJ&J - adenovirus basedSputnik V - adenovirus basedChina's SinoVac followed the established method of inactivated virus and CanSino went on ahead with adenovirus based.There are so many others in line. Each of these technologies have pros & cons. It's difficult to pitch one against the other. Why some scientists are worried is that there can be some cocerns with adenovirus based vaccines if not tested over long term. I mentioned this in another thread explaining why vaccine tests usually takes years. An experimental HIV vaccine developed by a US company had to be withdrawn because some researchers found that it actually raised the risk of HIV infection in some people. It took an year for this to surface, in fact nearly 18 months. The adenovirus is used as a vector and the failed HIV vaccine used an engineered strain known as adenovirus 5 (Ad5)The Cansino vaccine uses Ad5, the Russian one uses two vectors Ad5 and Ad26. Hence scientists are questioning as to why they still stick with Ad5 rather than going for another one when there are so many alternatives.To their defence the Russians argue that they used this for their Ebola vaccine platform and no harmful results were noticed and hence it's safe. China's Cansino also has a Ad5 based Ebola vaccine. Both of these used the established platform to modify it for Covid 19.I believe this Ad5 issue is why the Oxford Scientists chose another adenovirus vector. They used a harmless, weakened adenovirus that usually causes the common cold in chimpanzees. ChAdOx1.Hope this helps....</blockquote>

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