These include topical creams, such as Benzaclin, Klaron and Azelex, as well Tretinoin and Adapalene, to name but a few. These creams are helpful for clearing blocked pores. Some of these substances may have unfavorable side effects and should therefore, only be used on the recommendation and guidance of a qualified dermatologist. Topical creams may be effective for less serious to mild cases of acne. amoxicillin side effects