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අලුත් කොරෝනා වෛරස් ප්රභේද සහ අනාගතය
- Thread starter Bad_horse
- Start date
There are many in the drug race. Apart from the above mentioned PF-07321332 protease inhibitor, Pfizer also has two other candidates based on their Main Protease (M-pro) technology. This was developed when SARS epidemic started and was later abandoned around 2004.
It was found with Covid, the Mpro remains almost the same as that of SARS pathogen, and they had only to make minor changes to the original chemicals. Two were prepared and one went ahead for trials - Both of these were IV administered.
Then all of a sudden they started testing a different Oral candidate PF-07321332 last month.
There are a few other antivirals from the US, Canada, to Australia. Them seem to work in-vitro but it will take years for human trials to be over and get approved.
The Australian developed drug uses Gene-silencing RNA technology, destroying the COVID virus genome directly and stops the virus replication but expected to be approved by 2023. Time is the issue...
Meanwhile Nasal vaccine or a drug might show a better promise - because that''s where the infection begins. Many researchers are onto this too.
PS: Note : Sometimes where you start attacking the virus matters. I have mentioned this before. A well known instance is the Polio Vaccine. Poliovirus is spread through food or water contaminated with human excrement. The virus enters the body through the mucosa of the gut.
Professor Jonas Salk developed the vaccine from completely inactivated virus which was injected, somewhere in 1955.
Later, in 1960, Albert Sabin introduced a new polio vaccine, with a weakened poliovirus.. (not inactivated like the Salk vaccine)
But the most important thing to note was Sabin’s vaccine was swallowed, in the form of a sugar cube or a drop of liquid on a biscuit.
This method makes the vaccine into direct contact with the gut mucosa, with the result that it more effective than the Salk vaccine in blocking poliovirus infection.
It was found with Covid, the Mpro remains almost the same as that of SARS pathogen, and they had only to make minor changes to the original chemicals. Two were prepared and one went ahead for trials - Both of these were IV administered.
Then all of a sudden they started testing a different Oral candidate PF-07321332 last month.
There are a few other antivirals from the US, Canada, to Australia. Them seem to work in-vitro but it will take years for human trials to be over and get approved.
The Australian developed drug uses Gene-silencing RNA technology, destroying the COVID virus genome directly and stops the virus replication but expected to be approved by 2023. Time is the issue...
Meanwhile Nasal vaccine or a drug might show a better promise - because that''s where the infection begins. Many researchers are onto this too.
PS: Note : Sometimes where you start attacking the virus matters. I have mentioned this before. A well known instance is the Polio Vaccine. Poliovirus is spread through food or water contaminated with human excrement. The virus enters the body through the mucosa of the gut.
Professor Jonas Salk developed the vaccine from completely inactivated virus which was injected, somewhere in 1955.
Later, in 1960, Albert Sabin introduced a new polio vaccine, with a weakened poliovirus.. (not inactivated like the Salk vaccine)
But the most important thing to note was Sabin’s vaccine was swallowed, in the form of a sugar cube or a drop of liquid on a biscuit.
This method makes the vaccine into direct contact with the gut mucosa, with the result that it more effective than the Salk vaccine in blocking poliovirus infection.
spread wenna wenna aluth variants enawa
spread wena eka control karagena vaccine kaloth tamai iwara karaganna puluwan
salara kiwwoth mulu lokema corona vaccine walin nathi kalath wedak naha, eka ratak athule darunuwata spread wigena giyoth aluth variants enna puluwan. e aluth variant ara vaccine eken answer karanne natiwa ara ratawal walata spread wenna puluwan
ඔව් සරලව විකෘති වීම් ඇතිවෙන්නෙ පරිණාමය වෙන්න තමයි. විකෘති හිතා මතා ඇති වෙන්නෙ නෑ. ඒ කිව්වෙ වෛරස් එකට "තව බෝකරන්න ඕනෙ, මම පරිණාමය වෙන්න ඕනෙ" කියල හිතිල හිතා මතා විකෘති ඇති වෙන්නෙ නෑ. විකෘති ඇති වෙන්නෙ ඉබේම. ඒ කිව්වෙ වෛරසය අපේ සෛලයක් ඇතුලට ගිහින් ගුණනය වෙද්දි DNA/RNA දාමයේ නයිට්රජන් භෂ්ම අනුපිළිවෙල වෙනස් වෙලා විකෘති හැදෙන්නෙ. මම කලින් කිව්වත් වගේ විකෘති ඇති වෙන හැම එකම දරුණු වෙන්නෙ නෑ. හැම විකෘතියම වාසිදායක වෙන්නෙත් නෑ. සමහර විකෘති නිසා වෛරසයේ හැසිරීම් වෙනස් වෙනවා. මම හිතන්නෙ ඒක සම්භාවිතාවය කියලා. ඉන්න පරිසරයට මුහුණදෙන්න වැඩියෙන් පුලුවන් වෛරස ප්රමාණය හොඳින් හැදෙන්න ගන්නවා අනෙක් ප්රභේද අභිබවා. ඒක තමයි ස්වභාවිකවරණය. මුලින් ආපු ඒවට මිනිස්සුන්ට ප්රතිශක්තිකරණය ඇති වෙනකොට ඒවට ඔරොත්තු දෙන ඩෙල්ටා වගේ ප්රභේද ඒවා පැතිරෙනවා මොකද ප්රතිශක්තිකරණයට යට වෙන මුල් ප්රභේද වලට පැවැත්මක් නැති වෙන නිසා.
විකෘති වෛරස් විතරක් නෙවෙයි අපෙත් වෙනවා. අපේ සෛලයක DNA විකෘති වෙන එක වලක්වන්න proof read ඒ කිව්වේ සෝදුපත් කියවන ප්රෝටීන තියෙනවා. විකෘති හැදුනොත් ඒ සෛලය විනාශ කරන mechanism තියෙනවා. ඔය සෝදුපත් කියවගන්න බැරි හෝ මඟඇරෙන සෛල තමා පිළිකා විදියට ඇඟේ පැතිරෙන්නෙ. RNA වෛරස් වල ඔය සෝදුපත් කියනවන mechanism එක දකින්න ලැබෙන්න අඩුවෙන්. ඒත් වාසනාවකට SARS-CoV-2 එකේ proof reading තියෙනවා. ඒක නිසා විකෘති ඇතිවෙන වේගය අඩුයි. උදාහරණයක් විදියට proof reading නැති Influenza virus එක SARS-CoV-2 වගේ හතර ගුණයක වේගෙන් විකෘති හැදෙනවා. ඒකයි පිටරට flu vaccine අවුරුදු ගානෙ අලුතෙන් දෙන්න වෙන්නෙ.
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