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Message: <blockquote data-quote="nppcheguevara" data-source="post: 30750892" data-attributes="member: 583073">AI Overview <a href="https://support.google.com/websearch?p=ai_overviews&hl=en-LK" target="_blank">Learn more</a>Fipronil and amitraz, when combined, are used as topical treatments to control fleas, ticks, and chewing lice in dogs and puppies. The combination is designed to enhance the efficacy of fipronil alone against ticks, resulting in faster kill times and longer duration of activity.  Elaboration:<ul> <li data-xf-list-type="ul">Fipronil: This insecticide and acaricide is a member of the phenylpyrazole family. It works by binding to GABA receptors in invertebrate neurons, which blocks inhibitory nerve impulses, leading to paralysis and death of the insect or tick.</li> <li data-xf-list-type="ul"> </li> <li data-xf-list-type="ul">Amitraz: This acaricide also targets ectoparasites, specifically by acting on the octopamine receptor. </li> <li data-xf-list-type="ul"> </li> <li data-xf-list-type="ul">Synergistic Efficacy: When used together, fipronil and amitraz exhibit synergistic effects, meaning the combined action is greater than the sum of their individual actions. This results in a faster kill rate of ticks and a longer duration of protection compared to either active ingredient alone. </li> <li data-xf-list-type="ul"> </li> <li data-xf-list-type="ul">Certifect®: A common brand name for a topical medication containing fipronil, (S)-methoprene, and amitraz, used for treating and controlling fleas, ticks, and chewing lice in dogs. </li> <li data-xf-list-type="ul"> </li> <li data-xf-list-type="ul">Off-label Use: While primarily used in dogs and puppies, fipronil with S-methoprene and amitraz may be used off-label (extra label) to treat mites in ferrets, <a href="https://vcahospitals.com/know-your-pet/fipronil-with-smethoprene-and-amitraz-topical" target="_blank">according to VCA Animal Hospitals</a>. </li> <li data-xf-list-type="ul"> </li> <li data-xf-list-type="ul">Adverse Reactions: Some dogs may experience transient skin reactions, such as itching, redness, or hair loss at the application site, or other more serious reactions like pemphigus foliaceus in rare cases. <a href="https://ec.europa.eu/health/documents/community-register/2015/20150226131202/anx_131202_en.pdf" target="_blank">The European Commission</a> recommends contacting a veterinarian if adverse reactions occur.</li> </ul><hr /><a href="https://phenomenex.blog/2017/09/26/egg-fipronil-scare/" target="_blank">https://phenomenex.blog/2017/09/26/egg-fipronil-scare/</a>kiyawapam - bithtahra kana eka nawaththanna wei wage------ Post added on [DATETIME="UT"]1748448690[/DATETIME]</blockquote>

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