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Message: <blockquote data-quote="Fiona Dabare" data-source="post: 30750903" data-attributes="member: 586428">ඔය වගේ වල්/ කෘමි නාශක පොඩි මාත්‍රාවකින් කෑම එක්ක එන එකයි, එලියේ/ ඇතුලේ කිනිතුල්ලෝ මිලිය.. ඉද්දි උන්ව මරන්න ඕක හතරවටේ ගැහුවහම එක පාර ලොකු මාත්‍රාවකින් ශරීරගත වෙනයි දෙකක්<h3>Fipronil Toxicity in Humans</h3>Mechanism of action:<ul> <li data-xf-list-type="ul">Fipronil works by blocking GABA-gated chloride channels in insects, leading to excessive neuronal stimulation. In mammals, it has a similar action but with lower affinity.</li> </ul>Toxicity profile:<ul> <li data-xf-list-type="ul">Mild to moderate exposure: Nausea, vomiting, dizziness, headache, weakness.</li> <li data-xf-list-type="ul">Severe exposure: Seizures, agitation, tremors, altered mental status.</li> <li data-xf-list-type="ul">Chronic exposure: Some studies suggest possible liver, kidney, and thyroid effects in animals, but human data is limited.</li> <li data-xf-list-type="ul">Carcinogenicity: Classified as possibly carcinogenic (Group C) by the U.S. EPA, based on animal studies.</li> <li data-xf-list-type="ul">LD50 (oral, rat): ~97 mg/kg (moderate toxicity).</li> </ul><h3>Amitraz Toxicity in Humans</h3>Mechanism of action:<ul> <li data-xf-list-type="ul">Amitraz is an alpha-2 adrenergic agonist, similar in action to drugs like clonidine, affecting the central nervous system and sympathetic tone.</li> </ul>Toxicity profile:<ul> <li data-xf-list-type="ul">Common symptoms:<ul> <li data-xf-list-type="ul">CNS depression (drowsiness, coma)</li> <li data-xf-list-type="ul">Bradycardia (slow heart rate)</li> <li data-xf-list-type="ul">Hypotension</li> <li data-xf-list-type="ul">Hypothermia</li> <li data-xf-list-type="ul">Hyperglycemia</li> <li data-xf-list-type="ul">Miosis (small pupils)</li> </ul></li> <li data-xf-list-type="ul">Severe exposure: Respiratory depression, convulsions, and cardiovascular collapse.</li> </ul>LD50 (oral, rat): ~250–500 mg/kg (moderate toxicity).</blockquote>

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