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<blockquote data-quote="imhotep" data-source="post: 30350672" data-attributes="member: 562115"><p>I have seen people who got the ticket for the next world. Be careful. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite24" alt=":unsure:" title="Unsure :unsure:" loading="lazy" data-shortname=":unsure:" /></p><hr /><p></p><p></p><p>One American, one British, 2 Danes & 2 Australians. Very sad. Methyl poisoning is deadly unless diagnosed and treated immediately. </p><p></p><p>Methyl over 25 ml can be fatal without treatment. There are treatment protocols in place like immediate sodium bicarb and a shot of Ethyl alcohol. </p><p>Fomepizole should be considered as first line antidote. Fomepizole acts similarly to ethanol. It is a stronger competitive inhibitor of ADH (Alcohol Dehydrogenase) </p><p>Sometimes Fomepizole might not easily be available. Ethanol competes with methanol for ADH, thus preventing metabolism of methanol to its toxic by-products. ADH has a 10- to 20-fold greater affinity for ethanol than for methanol. </p><p>Fomepizole can give enough time for dialysis needs. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite3" alt=":-(" title="Frown :-(" loading="lazy" data-shortname=":-(" /></p><p>------ <span style="font-size: 10px">Post added on [DATETIME="UT"]1732319958[/DATETIME]</span></p></blockquote><p></p>
[QUOTE="imhotep, post: 30350672, member: 562115"] I have seen people who got the ticket for the next world. Be careful. :unsure: [HR][/HR] One American, one British, 2 Danes & 2 Australians. Very sad. Methyl poisoning is deadly unless diagnosed and treated immediately. Methyl over 25 ml can be fatal without treatment. There are treatment protocols in place like immediate sodium bicarb and a shot of Ethyl alcohol. Fomepizole should be considered as first line antidote. Fomepizole acts similarly to ethanol. It is a stronger competitive inhibitor of ADH (Alcohol Dehydrogenase) Sometimes Fomepizole might not easily be available. Ethanol competes with methanol for ADH, thus preventing metabolism of methanol to its toxic by-products. ADH has a 10- to 20-fold greater affinity for ethanol than for methanol. Fomepizole can give enough time for dialysis needs. :-( ------ [SIZE=2]Post added on [DATETIME="UT"]1732319958[/DATETIME][/SIZE] [/QUOTE]
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