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Message: <blockquote data-quote="imhotep" data-source="post: 26817407" data-attributes="member: 562115">I cannot say for sure... They have not provided with any details on the exact mechanism how this drug works.The only thing I can think of is a finding by the Belgian scientists that "Statins" can reduce the amount of cholesterol in the membranes of cells, and lower levels of cholesterol can prevent viruses from successfully entering cells.When the cholesterol level in the cell membrane is high, ACE2—the receptor the virus uses to invade cells—sits at a spot on the cell surface primed for endocytosis (this is how it gets into our cells).When cholesterol is low, ACE2 is present in a region that isn’t quite primed for endocytosis. - BUT - SARS-CoV-2 can still gain entry through a less efficient cell surface mechanism using the protein TMPRSS2.However, it's the the endocytic pathway which is the primary and more infectious pathway.Lowering cell membrane cholesterol levels, which statins could do if taken in advance of infection, can lead to less virus getting into the cell.Some others suspect that statins can interfere with the Covid virus main Protease - which is responsible for virus replication and transcription.Also there is a study from Sirrera-Leone in 2014 where they used statins to treat Ebola.  Around 100 individuals infected with the virus were treated with a combination of atorvastatin and an antihypertensive - irbesartan for five to six days. Many survived in this group. (Note - Typically more than half will die of Ebola normally)However, no one has done a detailed study on how long term statin users are affected by Covid. But according to what's mentioned above at least you stand a better chance.</blockquote>

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