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Message: <blockquote data-quote="imhotep" data-source="post: 27300138" data-attributes="member: 562115">Published in the Lancet 19 January 2022....Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs for specific pathogen–drug combinations in select locations. To our knowledge, this study presents the most comprehensive estimates of AMR burden to date.<h3>Findings</h3>On the basis of our predictive statistical models, there were an estimated 4·95 million (3·62–6·57) deaths associated with bacterial AMR in 2019, including 1·27 million (95% UI 0·911–1·71) deaths attributable to bacterial AMR. At the regional level, we estimated the all-age death rate attributable to resistance to be highest in western sub-Saharan Africa, at 27·3 deaths per 100 000 (20·9–35·3), and lowest in Australasia, at 6·5 deaths (4·3–9·4) per 100 000. Lower respiratory infections accounted for more than 1·5 million deaths associated with resistance in 2019, making it the most burdensome infectious syndrome. The six leading pathogens for deaths associated with resistance (Escherichia coli, followed by Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa) were responsible for 929 000 (660 000–1 270 000) deaths attributable to AMR and 3·57 million (2·62–4·78) deaths associated with AMR in 2019. One pathogen–drug combination, meticillin-resistant S aureus, caused more than 100 000 deaths attributable to AMR in 2019, while six more each caused 50 000–100 000 deaths: multidrug-resistant excluding extensively drug-resistant tuberculosis, third-generation cephalosporin-resistant E coli, carbapenem-resistant A baumannii, fluoroquinolone-resistant E coli, carbapenem-resistant K pneumoniae, and third-generation cephalosporin-resistant K pneumoniae.PS:  One of the co-author's comment (Lucien Swetschinski.) “Antimicrobial resistance is a global threat, from Western Europe, where the most advanced antibiotics are used, to Sub-Saharan Africa, where access to second-line therapies is limited,” he says.“Though the pathogens of most concern and strategies needed to control the threat differ by location, the implication is clear: if left unchecked, antimicrobial resistance will jeopardize global health systems and cost us millions of lives,” Also please refer to my old thread 19 Nov 2021 -  <a href="https://elakiri.com/threads/waaw-world-antimicrobial-awareness-week.2018878/" target="_blank">https://elakiri.com/threads/waaw-world-antimicrobial-awareness-week.2018878/</a></blockquote>

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