ASF - African Swine Fever

imhotep

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  • Mar 29, 2017
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    African swine fever virus is a large enveloped double-stranded DNA virus that is the sole member of the genus Asfivirus within the family Asfarviridae (Asfar=African swine fever and related viruses). African swine fever virus is the only known DNA arbovirus and is transmitted by soft ticks of the genus Ornithodoros. Virus strains are distinguished by their virulence to swine, which ranges from highly lethal to subclinical infection.

    Asfarvirus virions are enveloped, approximately 200 nm in diameter, and possess a nucleocapsid core that is surrounded by internal lipid layers and a complex icosahedral capsid. The capsid consists of a hexagonal arrangement of structural units, each of which appears as a hexagonal prism with a central hole. The genome consists of a single molecule of linear double-stranded DNA, 170–190 kbp in size, depending on the virus strain.

    ASF virus is remarkably resilient, able to survive from days to months within the soil of pigpens, pork meat and pig products, or on people’s clothing. Curing meat won’t necessarily kill the virus. Neither will repeated freezing and thawing or cooking at 56 degrees Celsius for over an hour.

    Note that the virus is not a direct threat to humans. It cannot be transmitted to people, and properly prepared pork products are safe to eat. It's not Swine Flu, which is H1N1 which can infect both humns and pigs.

    The only way to prevent further escalation is to contain the disease and cull the animals. Though humans don't get infected their actions casuse the disease to spread. That's why everyone has to be responsible and stick to control measures.

    There's no definitive vaccine as yet even though the disease existed since 1921. :unsure:
     

    NRTG

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  • Oct 19, 2019
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    Colombo, Sri Lanka
    properly prepared pork products are safe to eat.
    At Last GIF by VERZUZ
     
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    imhotep

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  • Mar 29, 2017
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    TFS brother. :dull:(y)

    It's safe to eat because virus cannot enter into human cells. The exact mechanism is not yet fully understood but studies show that ASFV enters host cells through multiple mechanisms. This includes a receptor-dependent form of endocytosis, known as Clathrin-Mediated Endocytosis (CME) , and is dependent on temperature, energy, cholesterol and low pH. Clathrin-mediated endocytosis (CME) is a common entry pathway for many viruses, including large DNA viruses.

    ASF virus targets macrophages and monocytes in swine cells for entry and replication, although the identity of cellular receptors targeted by the virus for host cell entry are unknown. It is possible that the virus uses some specialized receptors on the host cell surface that are absent in non-susceptible species or certain steps in viral replication or maturation may not be supported in non-sensitive species.

    So far, only domestic pigs and wild boars (warthogs and bushpigs) are susceptible to the virus,

    PS: Low levels of ASF virus replication in human cell lines like Vero and HEK293T cells have been achieved by continuous passaging and adaptation. However, the adapted virus is less infectious in swine macrophages compared to the wild-type strain.

     
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