Early Lung Cancer Detection - Nanosensors by MIT.

imhotep

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  • Mar 29, 2017
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    Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.

    The new diagnostic is based on nanosensors that can be delivered by an inhaler or a nebulizer. If the sensors encounter cancer-linked proteins in the lungs, they produce a signal that accumulates in the urine, where it can be detected with a simple paper test strip.

    This approach could potentially replace or supplement the current gold standard for diagnosing lung cancer, low-dose computed tomography (CT). It could have an especially significant impact in low- and middle-income countries that don't have widespread availability of CT scanners, the researchers say.

    These sensors consist of polymer nanoparticles coated with a reporter, such as a DNA barcode, that is cleaved from the particle when the sensor encounters enzymes called proteases, which are often overactive in tumors. Those reporters eventually accumulate in the urine and are excreted from the body.

    Previous versions of the sensors, which targeted other cancer sites such as the liver and ovaries, were designed to be given intravenously. For lung cancer diagnosis, the researchers wanted to create a version that could be inhaled, which could make it easier to deploy in lower resource settings.

    Also Phase I trials for a similar sensor for use in diagnosing liver cancer and a form of hepatitis known as nonalcoholic steatohepatitis (NASH) is already on the way.
     

    imhotep

    Well-known member
  • Mar 29, 2017
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    තාක්ෂනේ කොච්චර දියුනු වෙලාද :yes:
    True... We go behind snake oil and other remedies fooling ourselves. :(

    Copied from one of my older posts....

    Since the latter part of 2021 there are blood tests that can detect more than 50 types of cancer from a single blood sample. How this is done is by detecting the trace amounts of tumour DNA in the bloodstream. It's like finding the proverbial needle in a haystack, but the present day technology has enabled this to be done. Simple blood tests have now come a long way...
    These traces of cancer DNA carries a “molecular barcode” embedded that identifies the tissue it came from. These barcodes are a result of DNA methylation, naturally existing modifications to the surface of DNA that vary for each type of tissue in the body. Thus a lung tissue has a different DNA methylation pattern than breast tissue.
    Additionally, the cancer cells have abnormal DNA methylation patterns that correlate with cancer type. This enables these tests to focus on the sections of DNA that distinguish between cancerous and normal tissue and exactly pinpoint the cancer’s origin site.

    PS:
    These tests are expensive, around $1000 per test. Hopefully one day, once the research costs are covered and lab equipment costs go down could be available. Even certain advanced cancer cell biopsy tests are not available in SL yet. Even years after its use - these still can cost over $500.