How antivenom being produced?

[DjAnomaly]

I wonder any antivenom could cure covid Pneumonia?

 

[Night Rider]

Interesting...

 

[NRTG]

BUMP

 

[imhotep]

FYI... A copy of my earlier posts....

Anti-venoms are purified antibodies against venoms or venom components. First of all, the venom is obtained from the snakes by milking and other creatures by invasive techniques. Then small doses of venom is injeted into an animal, and the dose gradually increased as the animal builds up a tolerance to the venom. The animal produces antibodies to the venom. When the doses being injected are large, the amount of antibody produced is large.
These antibodies are harvested by taking blood off from the animals and separating out the antibodies followed by a purification process.
These are subsequently injected into a patient, and the binding sites on the antibody fragments bind to the venoms thus neutralising effect. This technique is very old and used since the 1890s.

But, somewhere around 2015, scientists found that the mRNA encoding the toxins in snakebite venom can be recovered directly from venom. This paved the way for the feasibility of using venom-derived RNA for future antivenom applications. At that time the mRNA stabilizing over long term and purification were not advanced like today but the ideas and the work continued. This method has the advantage that all you need is the venom, without any harm to the poisonous creature or the use of an animal to develop antibodies.
The mRNA will function just like the Pfizer/Moderna vaccines for the body to produce antibodies for the venom.

That's the two major differences in the mRNA and the anti-venom approach.

Note that the mRNA technology is not limited only for Covid vaccines. Cancer vaccines, Protein replacement therapy – A wide range of diseases can be treated using mRNA to express proteins- the lungs, liver, and heart - Gene therapy, Cell reprogramming etc.
The Covid epidemic will accelerate the developments in all these areas as the fear of mRNA has gone away.

PS: Snake venom has given birth to some drugs. eg Captopril for Hypertension- The first of the ACE inhibitors somewhere in 1980 was from snakes.

PPS: I am not aware of any Covid drugs being developed. But there are teams on it. The PLA2 enzymes in snake venom can kill the Covid virus.

 

[topkollek]

FYI... A copy of my earlier posts....

Anti-venoms are purified antibodies against venoms or venom components. First of all, the venom is obtained from the snakes by milking and other creatures by invasive techniques. Then small doses of venom is injeted into an animal, and the dose gradually increased as the animal builds up a tolerance to the venom. The animal produces antibodies to the venom. When the doses being injected are large, the amount of antibody produced is large.
These antibodies are harvested by taking blood off from the animals and separating out the antibodies followed by a purification process.
These are subsequently injected into a patient, and the binding sites on the antibody fragments bind to the venoms thus neutralising effect. This technique is very old and used since the 1890s.

But, somewhere around 2015, scientists found that the mRNA encoding the toxins in snakebite venom can be recovered directly from venom. This paved the way for the feasibility of using venom-derived RNA for future antivenom applications. At that time the mRNA stabilizing over long term and purification were not advanced like today but the ideas and the work continued. This method has the advantage that all you need is the venom, without any harm to the poisonous creature or the use of an animal to develop antibodies.
The mRNA will function just like the Pfizer/Moderna vaccines for the body to produce antibodies for the venom.

That's the two major differences in the mRNA and the anti-venom approach.

Note that the mRNA technology is not limited only for Covid vaccines. Cancer vaccines, Protein replacement therapy – A wide range of diseases can be treated using mRNA to express proteins- the lungs, liver, and heart - Gene therapy, Cell reprogramming etc.
The Covid epidemic will accelerate the developments in all these areas as the fear of mRNA has gone away.

As I understood OP was asking whether there are any evidence supporting use of antivenom against covid virus. Anyway I learnt something from your post.

 

[DjAnomaly]

FYI... A copy of my earlier posts....

Anti-venoms are purified antibodies against venoms or venom components. First of all, the venom is obtained from the snakes by milking and other creatures by invasive techniques. Then small doses of venom is injeted into an animal, and the dose gradually increased as the animal builds up a tolerance to the venom. The animal produces antibodies to the venom. When the doses being injected are large, the amount of antibody produced is large.
These antibodies are harvested by taking blood off from the animals and separating out the antibodies followed by a purification process.
These are subsequently injected into a patient, and the binding sites on the antibody fragments bind to the venoms thus neutralising effect. This technique is very old and used since the 1890s.

But, somewhere around 2015, scientists found that the mRNA encoding the toxins in snakebite venom can be recovered directly from venom. This paved the way for the feasibility of using venom-derived RNA for future antivenom applications. At that time the mRNA stabilizing over long term and purification were not advanced like today but the ideas and the work continued. This method has the advantage that all you need is the venom, without any harm to the poisonous creature or the use of an animal to develop antibodies.
The mRNA will function just like the Pfizer/Moderna vaccines for the body to produce antibodies for the venom.

That's the two major differences in the mRNA and the anti-venom approach.

Note that the mRNA technology is not limited only for Covid vaccines. Cancer vaccines, Protein replacement therapy – A wide range of diseases can be treated using mRNA to express proteins- the lungs, liver, and heart - Gene therapy, Cell reprogramming etc.
The Covid epidemic will accelerate the developments in all these areas as the fear of mRNA has gone away.

PS: Snake venom has given birth to some drugs. eg Captopril for Hypertension- The first of the ACE inhibitors somewhere in 1980 was from snakes.

PPS: I am not aware of any Covid drugs being developed. But there are teams on it. The PLA2 enzymes in snake venom can kill the Covid virus.

Not all types of venom is appropriate though ex:- neurotoxins, haemotoxic, cytotoxic, etc. Specific type of venom maybe suitable. You don't need to catch a snake but a sea snail like creature's potent venom would be beneficial.

 

[hodakolla]

BUMPER

 

[TFSC]

Nice