Israeli company is set to become first in the world to launch clinical trials of an ORAL COVID-19 vaccine

sriamerican

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  • Aug 2, 2020
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    • Oravax Medical, a subsidiary of Jerusalem-based Oramed Pharmaceuticals, is developing an oral COVID-19 vaccine
    • The oral vaccine targets three proteins on the virus rather then the single spike protein that the Pfizer-BioNTech and Moderna vaccines target
    • Researchers say it is faster, cheaper and easier to manufacture than injectable and can be distributed to poorer countries
    • The team will first test if one or two pills are more effective and then compare the vaccine to a placebo
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    imhotep

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  • Mar 29, 2017
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    Thanks for the post.. Replied thinking it was a Nasal vaccine. Removed the comments as noticed that it's an Oral vaccine. Bharat-BioTech also developing one, a derivation of their single dose Nasal vaccine into an oral form. But still under development. There are a couple of others too in the UK & Europe.

    PS: Vaccine delivery doesn't have to be always in injection form. Nasal delivery, oral and Skin transfer (DNA vaccines) is also possible.

    A well known instance is the Polio Vaccine. Poliovirus is spread through food or water contaminated with human excrement. The virus enters the body through the mucosa of the gut.
    Then it infects the nervous system, causing paralysis. The famous scientist Jonas Salk developed the vaccine from completely inactivated virus which was injected, somewhere in 1955.

    In 1960, Albert Sabin introduced a new polio vaccine, with a weakened poliovirus.. (not inactivated like the Salk vaccine)
    But the most important thing to note was Sabin’s vaccine was swallowed, in the form of a sugar cube or a drop of liquid on a biscuit.
    This method makes the vaccine into direct contact with the gut mucosa, with the result that it more effective than the Salk vaccine in blocking poliovirus infection.
     
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