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ElaKiri.com
News and Updates
MHRA - UK approves Molnupiravir
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<blockquote data-quote="imhotep" data-source="post: 27059527" data-attributes="member: 562115"><p>Please read my other thread on the link shown. Molnupiravir is an antiviral in the category of mutagenic ribonucleosides. It can change the viral genetic material and introduce errors to prevent replication and transcription of the viral genome. It's even capable to defeat the virus' proof reading mechansim to a certain extent. (Covid virus encode an RNA proofreading exoribonuclease (nsp14-ExoN) that is responsible for high-fidelity RNA synthesis.)</p><p></p><p>Inside the host cell, molnupiravir is converted to molnupiravir triphosphate. When the virus tries to replicate, molnupiravir triphosphate is incorporated into the viral RNA instead of the nucleoside cytidine, causing a mutation.</p><p></p><p>The mutation stops the virus from replicating keeping the virus counts low and thus lowering the disease severity. This causes concern that the drug might cause cancers or birth abnormalities. Tests have been done but none available in the public domain but certainly submitted to the authorities concerned.</p></blockquote><p></p>
[QUOTE="imhotep, post: 27059527, member: 562115"] Please read my other thread on the link shown. Molnupiravir is an antiviral in the category of mutagenic ribonucleosides. It can change the viral genetic material and introduce errors to prevent replication and transcription of the viral genome. It's even capable to defeat the virus' proof reading mechansim to a certain extent. (Covid virus encode an RNA proofreading exoribonuclease (nsp14-ExoN) that is responsible for high-fidelity RNA synthesis.) Inside the host cell, molnupiravir is converted to molnupiravir triphosphate. When the virus tries to replicate, molnupiravir triphosphate is incorporated into the viral RNA instead of the nucleoside cytidine, causing a mutation. The mutation stops the virus from replicating keeping the virus counts low and thus lowering the disease severity. This causes concern that the drug might cause cancers or birth abnormalities. Tests have been done but none available in the public domain but certainly submitted to the authorities concerned. [/QUOTE]
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