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Message: <blockquote data-quote="imhotep" data-source="post: 27018853" data-attributes="member: 562115">Imagine if we had no vaccines.... Just take the case of Polio. It took 30 years after the vaccine to beat it, but even today it raises its ugly head in areas where the vaccination system failed. It's on the increase because of Covid. India ran a massive polio vaccination drive recently in response. The annual number of wild poliovirus cases has declined by more than 99.9% worldwide from an estimated 350,000 in 1988 when the Global Polio Eradication Initiative was launched.As for your second about virus mutations.... Protein folding is governed by the thermodynamic principle of Gibbs Free Energy (ΔΔG), which states that the amino acid sequence of a protein determines its native structure. This native structure has the minimum ΔΔG.Prediction of the changes in ΔΔG are routinely used in protein engineering and design for optimization of enzymes or stabilisation of protein complexes.A team of researchers at the Department of Medical Physics and Biomedical Engineering at the UCL did a study on the ΔΔG values of the general population of mutations and the variants. They calculated the ΔΔG for every possible missense mutation in the S-protein, which amounted to a total of 19,440 mutations.</blockquote>

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