Natural Selection vs. Medicines

[saw1993]

ඔය ලෙඩ වලට බෙහෙත් හොයාගන්න එකෙන් , "Survival of the Fittest" theory එකෙන් පිටට අපි යනවා නේද? එතකොට අපි අතර Weaker Gene එකත් බෙහෙත් අරගෙන survive වෙන්වා නේද? දීර්ඝකාලීනව ලෙඩ වැඩි වෙලා බෙහෙත් වලින්ම ජීවත් වෙන්න වෙයි නේද? ලෙඩ වලට අපේ ශරීරය අනුගත වෙන්න තියෙන අවස්ථා අඩු වෙන්වා නේද?

PS : This is just a thought for discussion, I did't say we don't want medicines or vaccines.

 

[prabo22]

සැම ජීවියෙක්ටම ජීවත් වීමෙ අයිතියක් ඇත,, පව් කාරයා

 

[imhotep]

"Survival of the fittest" isn't "Natural Selection". In fact it wasn't Darwin who said "Survival of the Fittest" - It was by another Englishman named Herbert Spencer who laid the groundwork for what's called "Social Darwinism"
There's a lot more to evolution by selection than survival of the fittest. Modern medicine does not counter natural selection... It could change the selection pressure parameters.

 

[saw1993]

සැම ජීවියෙක්ටම ජීවත් වීමෙ අයිතියක් ඇත,, පව් කාරයා

ow, eth long run ekedi , humans gene's weaker wela medicines nathuwama bari wenwa neda? Dn unath younger generation eka godak chronical diseases walata beheth gannwa. Ewa nathuwa survive wenna ba. minissu beheth walata purudu wela. issra leda haduna nam daraganna bari na maruna, e weaker gene eka ethanin iwrai. Strongr eka survive wenwa. Eth dan behet walin weaker gene ekath survive wenwa issraata geniyanawa,

mm kiyanne na medicnes denna epa marenna arinna ona kiyala , mta nikan hithuna deyak , sanwadayata deyak.

"Survival of the fittest" isn't "Natural Selection". In fact it wasn't Darwin who said "Survival of the Fittest" - It was by another Englishman named Herbert Spencer who laid the groundwork for what's called "Social Darwinism"
There's a lot more to evolution by selection than survival of the fittest. Modern medicine does not counter natural selection... It could change the selection pressure parameters.

Yup , but I think those parameter's affects the natural selection. As an example let's take this Covid. There are some fellows having immunity against the virus in themselves. Without any vaccines they survive. But for those who have weaker immunity , needs a vaccine. From modern medicine they get the immunity boost and survive. But will this vaccine adapt genes accordingly? I don't think. They need the booster vaccine frequetly.

If there's no vaccine , only the fittest may survive and the future generations also shows resistant to this virus. No Weaker gene's

PS : This is just a thought for discussion, I did't say we don't want medicines or vaccines.

 

[NRTG]

BUMP

 

[hodakolla]

BUMPER

 

[imhotep]

ow, eth long run ekedi , humans gene's weaker wela medicines nathuwama bari wenwa neda? Dn unath younger generation eka godak chronical diseases walata beheth gannwa. Ewa nathuwa survive wenna ba. minissu beheth walata purudu wela. issra leda haduna nam daraganna bari na maruna, e weaker gene eka ethanin iwrai. Strongr eka survive wenwa. Eth dan behet walin weaker gene ekath survive wenwa issraata geniyanawa,

mm kiyanne na medicnes denna epa marenna arinna ona kiyala , mta nikan hithuna deyak , sanwadayata deyak.

Yup , but I think those parameter's affects the natural selection. As an example let's take this Covid. There are some fellows having immunity against the virus in themselves. Without any vaccines they survive. But for those who have weaker immunity , needs a vaccine. From modern medicine they get the immunity boost and survive. But will this vaccine adapt genes accordingly? I don't think. They need the booster vaccine frequetly.

If there's no vaccine , only the fittest may survive and the future generations also shows resistant to this virus. No Weaker gene's

PS : This is just a thought for discussion, I did't say we don't want medicines or vaccines.

With Covid if there wasn't a vaccine then some individuals who can mount a strong initial attack would survive. But note that it's not the young, strong or most athletic individuals who are guaranteed to survive.
There are no biomarkers to find who are immune, but there are five or six biomarkers to assess whether you will head for disaster. These tests are not normally done on patients.

As for your second statement , note that Covid has many variants and resistance to one doesn't doesn't make you resistant to all the variants including what's yet to come.

Hope the pan-coronavirus will succeed in 2023. Currently as a drug only Molnupiravir is awaiting FDA approval. But there are concerns with this drug. It will not be given to pregnant mothers.

 

[greenthunder]

ඔය ලෙඩ වලට බෙහෙත් හොයාගන්න එකෙන් , "Survival of the Fittest" theory එකෙන් පිටට අපි යනවා නේද? එතකොට අපි අතර Weaker Gene එකත් බෙහෙත් අරගෙන survive වෙන්වා නේද? දීර්ඝකාලීනව ලෙඩ වැඩි වෙලා බෙහෙත් වලින්ම ජීවත් වෙන්න වෙයි නේද? ලෙඩ වලට අපේ ශරීරය අනුගත වෙන්න තියෙන අවස්ථා අඩු වෙන්වා නේද?

PS : This is just a thought for discussion, I did't say we don't want medicines or vaccines.

එහෙම වෙන්න තිබ්බා පැතජන් වෙනස් නොවී තියෙනවානම් නේද? ඒවාත් විකෘති ඇතිවීමෙන් වෙනස් වෙනවා කියනවනෙ. අපි වෙනස් වෙනවා වගේම රෝග කාරකත් වෙනස් වෙනකොට හැමදාම සිදුවිය යුතු අරගලයක් ඇරෙන්න "ෆිටස්ට්ම" කට්ටියක් හැදීමක් සිද්ද වෙනවද?

 

[saw1993]

With Covid if there wasn't a vaccine then some individuals who can mount a strong initial attack would survive. But note that it's not the young, strong or most athletic individuals who are guaranteed to survive.
There are no biomarkers to find who are immune, but there are five or six biomarkers to assess whether you will head for disaster. These tests are not normally done on patients.

As for your second statement , note that Covid has many variants and resistance to one doesn't doesn't make you resistant to all the variants including what's yet to come.

Hope the pan-coronavirus will succeed in 2023. Currently as a drug only Molnupiravir is awaiting FDA approval. But there are concerns with this drug. It will not be given to pregnant mothers.

I agree with you. There may be a series of vaccine generations for Covid in future (like antibiotics) .
The reason why I post this thought is , Considerable no of the youngsters are now having medicnes for chronical diseases . Which is not happened few decades earlier. This may be even higher in the future. Food habits also may be a reason, but I think we break the nature's selection cycle.

No medicines means no survival?

එහෙම වෙන්න තිබ්බා පැතජන් වෙනස් නොවී තියෙනවානම් නේද? ඒවාත් විකෘති ඇතිවීමෙන් වෙනස් වෙනවා කියනවනෙ. අපි වෙනස් වෙනවා වගේම රෝග කාරකත් වෙනස් වෙනකොට හැමදාම සිදුවිය යුතු අරගලයක් ඇරෙන්න "ෆිටස්ට්ම" කට්ටියක් හැදීමක් සිද්ද වෙනවද?

Hamadama Filter wevi refine wenawa wage mata nam therenne. Virus eka Mutate wenwa survive wenna , ehema nathi ewa vinasha wenwa. Minissu vaccines hadala survive wenwa.

 

[imhotep]

I agree with you. There may be a series of vaccine generations for Covid in future (like antibiotics) .
The reason why I post this thought is , Considerable no of the youngsters are now having medicnes for chronical diseases . Which is not happened few decades earlier. This may be even higher in the future. Food habits also may be a reason, but I think we break the nature's selection cycle.

No medicines means no survival?



Hamadama Filter wevi refine wenawa wage mata nam therenne. Virus eka Mutate wenwa survive wenna , ehema nathi ewa vinasha wenwa. Minissu vaccines hadala survive wenwa.

Imagine if we had no vaccines.... Just take the case of Polio. It took 30 years after the vaccine to beat it, but even today it raises its ugly head in areas where the vaccination system failed. It's on the increase because of Covid. India ran a massive polio vaccination drive recently in response.
The annual number of wild poliovirus cases has declined by more than 99.9% worldwide from an estimated 350,000 in 1988 when the Global Polio Eradication Initiative was launched.

As for your second about virus mutations....
Protein folding is governed by the thermodynamic principle of Gibbs Free Energy (ΔΔG), which states that the amino acid sequence of a protein determines its native structure. This native structure has the minimum ΔΔG.
Prediction of the changes in ΔΔG are routinely used in protein engineering and design for optimization of enzymes or stabilisation of protein complexes.

A team of researchers at the Department of Medical Physics and Biomedical Engineering at the UCL did a study on the ΔΔG values of the general population of mutations and the variants. They calculated the ΔΔG for every possible missense mutation in the S-protein, which amounted to a total of 19,440 mutations.