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Message: <blockquote data-quote="imhotep" data-source="post: 26382615" data-attributes="member: 562115">Yes... this was noted early Covid days that secretory IgA plays a role... but only useful as a diagnostic. I think no one did a proper study or that even this acts as a real barrier.The issue with Covid is that it compromises the balance between ACE1 and ACE2 receptors. The spike protein is able to do this without the virus. ACE2 is anti-inflammatory while the other one is the opposite. With ACE2 affected by the Spike protein (Note - The virus need not to be in this action) the ACE1 dominates and hence the endothelium gets into trouble.Hope someone will find a fix , now since the mechanism is known.</blockquote>

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