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New multi-antibody cocktail that protects against Covid-19
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<blockquote data-quote="imhotep" data-source="post: 26683057" data-attributes="member: 562115"><p>Researchers in Canada has come up with a new multi-antibody cocktail that works against Covid-19. When tested with hamsters, it suppressed replication-competent viral titers to undetectable levels in the animals’ lungs.</p><p>It's named TATX-03 and studies show that it <strong>maintained <em>in vitro</em> neutralizing activity</strong> against the B<strong>.1.1.7 (alpha), B.1.351 (beta) and P.1 (gamma)</strong> variants of concern.</p><p>Also further studies showed virus neutralization potency (in vitro) is also <strong>not affected</strong> by the rapidly spreading <strong>Delta variant (B.1.617.2</strong>).</p><p></p><p>One of their scientists stated " “Our TATX-03 cocktail is rationally designed for broad epitope coverage relying on multiple antibodies, which have shown in pre-clinical studies to work synergistically together, to reduce the risk of mutagenic escape, and have the potential to reduce the risk of new variants. We believe this strategy of multi-antibody cocktails is more crucial now with the surge of new variants of concern and breakthrough cases.”</p><p></p><p>Basically TATX-03 has the potential of being used as a therapy for SARS-CoV-2 infection with resistance to mutagenic escape.</p></blockquote><p></p>
[QUOTE="imhotep, post: 26683057, member: 562115"] Researchers in Canada has come up with a new multi-antibody cocktail that works against Covid-19. When tested with hamsters, it suppressed replication-competent viral titers to undetectable levels in the animals’ lungs. It's named TATX-03 and studies show that it [B]maintained [I]in vitro[/I] neutralizing activity[/B] against the B[B].1.1.7 (alpha), B.1.351 (beta) and P.1 (gamma)[/B] variants of concern. Also further studies showed virus neutralization potency (in vitro) is also [B]not affected[/B] by the rapidly spreading [B]Delta variant (B.1.617.2[/B]). One of their scientists stated " “Our TATX-03 cocktail is rationally designed for broad epitope coverage relying on multiple antibodies, which have shown in pre-clinical studies to work synergistically together, to reduce the risk of mutagenic escape, and have the potential to reduce the risk of new variants. We believe this strategy of multi-antibody cocktails is more crucial now with the surge of new variants of concern and breakthrough cases.” Basically TATX-03 has the potential of being used as a therapy for SARS-CoV-2 infection with resistance to mutagenic escape. [/QUOTE]
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