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ElaKiri Talk!
Pfizer vaccine for COVID-19: What are the side effects?
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<blockquote data-quote="warwickuni" data-source="post: 26346111" data-attributes="member: 101444"><p>We still do not know the long term effects of any of the vaccines. so it is unfair to single out any at this moment. Oxford -AZ is a the Only Vaccine that is sold at Cost. This may be due to its origin in University of Oxford and internationally reputed specialized Ivor Jennings Institute for Vaccines.</p><p>All vaccines have risks including what we are using at the moment for other diseases -eg MMR</p><p>Pfizer (developed by German BioNTec - Two Polish-German husband and wife ) uses nano particals made from lipo proteins to transport m-RNA to cytoplasm . These particles are unstable and m-RNA is also unstable hence need minus 70 to -80 centigrade (which is impossible for developing countries like India and Sri Lanka to administer quickly islanded)</p><p>Moderna (whose first drug is this) , uses the same method as Pfizer but their nano particale is more stable so do not need extreme temperatures such as -80 centigrade. Yet the particles and m-RNA are very unstable and vaccine needs to handled with extreme care(eg if you shake it it will be useless!)</p><p>So there are limitations for these two in developing contries. These two methods were never used for vaccination in human history and we are yet to observe after effects.</p><p>AZ used DNA and this is more stable for vector uses a more widely used vaccination method by using an adinovirus - a virus from chimpanzee.</p><p>There is a research done by Oxford Uni where it had concluded that risk of blood clotting is inherent in all vaccines(this is yet to be reviewed by others in the field- but not rejected.)</p><p>So do not throw the Baby with bathing water!</p><p>AZ is still the cheapest and best vaccination we have specially to countries like SL and India considering all the factors relating to vaccine roll out. The success of elimination of sickness does not depend on vaccine but the roll-out. If there are lot of issues in roll-out the virus may get over them quickly.</p></blockquote><p></p>
[QUOTE="warwickuni, post: 26346111, member: 101444"] We still do not know the long term effects of any of the vaccines. so it is unfair to single out any at this moment. Oxford -AZ is a the Only Vaccine that is sold at Cost. This may be due to its origin in University of Oxford and internationally reputed specialized Ivor Jennings Institute for Vaccines. All vaccines have risks including what we are using at the moment for other diseases -eg MMR Pfizer (developed by German BioNTec - Two Polish-German husband and wife ) uses nano particals made from lipo proteins to transport m-RNA to cytoplasm . These particles are unstable and m-RNA is also unstable hence need minus 70 to -80 centigrade (which is impossible for developing countries like India and Sri Lanka to administer quickly islanded) Moderna (whose first drug is this) , uses the same method as Pfizer but their nano particale is more stable so do not need extreme temperatures such as -80 centigrade. Yet the particles and m-RNA are very unstable and vaccine needs to handled with extreme care(eg if you shake it it will be useless!) So there are limitations for these two in developing contries. These two methods were never used for vaccination in human history and we are yet to observe after effects. AZ used DNA and this is more stable for vector uses a more widely used vaccination method by using an adinovirus - a virus from chimpanzee. There is a research done by Oxford Uni where it had concluded that risk of blood clotting is inherent in all vaccines(this is yet to be reviewed by others in the field- but not rejected.) So do not throw the Baby with bathing water! AZ is still the cheapest and best vaccination we have specially to countries like SL and India considering all the factors relating to vaccine roll out. The success of elimination of sickness does not depend on vaccine but the roll-out. If there are lot of issues in roll-out the virus may get over them quickly. [/QUOTE]
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