Linux runs on many architectures, not just Intel, and there are many versions of Linux, many packaging systems, and many shells. But most obvious to the end user, Linux mail clients and address books are far from standardized. KMail, Mozilla Mail, Evolution, pine, mutt, emacs ... the list goes on. It's simply not like the Windows world, in which Microsoft's email programs - Outlook and Outlook Express - dominate. In the Windows world, a virus writer knows how the monoculture operates, so he can target his virus, secure in the knowledge that millions of systems have the same vulnerability. A virus targeted to a specific vulnerability in Evolution, on the other hand, might affect some people, but not everyone using Linux. The growth of the Microsoft monoculture in computing is a dangerous thing for users of Microsoft products, but also for all computing users, who suffer the consequences of disasters in that environment, such as wasted network resources, dangers to national security, and lost productivity (note: the link is to a 880 kb PDF file).
Now that we've looked at the social engineering side of things, let's examine software design for reasons why Linux (and Mac OS X) is better designed than Microsoft when it comes to email security. Microsoft continually links together its software, often not for technical reasons, but instead for marketing or business development reasons (see the previous link for corroboration). For instance, Outlook Express and Outlook both use the consistently-buggy Internet Explorer to view HTML-based emails. As a result, a hole in IE affects OE. Linux email readers don't indulge in such behavior, with two exceptions: Mozilla Mail uses the Gecko engine that powers Mozilla to view HTML-based email, while KMail relies on the KHTML engine that the Konqueror browser uses. Fortunately, both Mozilla and the KDE Project have excellent records when it comes to security.
Further, the email programs themselves are designed to act in a more secure manner. The default behavior of the email program I prefer - KMail - is to not load external references in messages, such as pictures and Web bugs, and to not display HTML. When an HTML-based email shows up in my Inbox, I see only the HTML code, and a message appears at the top of the email: "This is an HTML message. For security reasons, only the raw HTML code is shown. If you trust the sender of this message then you can activate formatted HTML display for this message by clicking here." But even after I activate the HTML, certain dynamic elements that can be introduced in an HTML-based email - like Java, Javascript, plugins and even the "refresh" META tag - do not display, and cannot even be enabled in KMail.
Finally, if there is an attachment, it does not automatically run ... ever. Instead, I have to click it, and when I do, I get a dialog box offering me three options: "Save As ..." (the default), "Open With ...", and "Cancel". If I have mapped a file type to a specific program - for instance, I have associated PDFs with the PS/PDF Viewer, then "Open With ..." instead says "Open", and if I choose "Open", then the file opens in the PS/PDF Viewer. However, in either case, the dialog box always contains a warning advising the user that attachments can compromise security. This is all good, very good.
For all these reasons, even if a few individuals got infected with a virus due to extremely foolish behavior, it's unlikely the virus would spread to other machines. Unlike Sobig.F, which is the fastest spreading virus ever, a Linux-based Virus would fizzle out quickly. Windows is an inviting petri dish for viruses and worms, while Linux is a hostile environment for such nasties.