FYI. This is posted because of the misinformation posted in this forum. This is a recent study with 42,200,614 people aged 13 years or more.
ABSTRACT
In an updated self-controlled case series analysis of 42,200,614 people aged 13 years or more, we evaluate the association between COVID-19 vaccination and myocarditis, stratified by age and sex, including 10,978,507 people receiving a third vaccine dose. Myocarditis risk was increased during 1-28 days following a third dose of BNT162b2 (IRR 2.02, 95%CI 1.40, 2.91). Associations were strongest in males younger than 40 years for all vaccine types with an additional 3 (95%CI 1, 5) and 12 (95% CI 1,17) events per million estimated in the 1-28 days following a first dose of BNT162b2 and mRNA-1273, respectively; 14 (95%CI 8, 17), 12 (95%CI 1, 7) and 101 (95%CI 95, 104) additional events following a second dose of ChAdOx1, BNT162b2 and mRNA-1273, respectively; and 13 (95%CI 7, 15) additional events following a third dose of BNT162b2, compared with 7 (95%CI 2, 11) additional events following COVID-19 infection. An association between COVID-19 infection and myocarditis was observed in all ages for both sexes but was substantially higher in those older than 40 years. These findings have important implications for public health and vaccination policy.PS: To explain further...
The results reported that over the 1 to 28 days post-vaccination, an association was observed with the first dose of BNT162b2 and ChAdOx1 but not the mRNA-1273 vaccine. However, after the second dose, the risk of association was higher with mRNA-1273 as compared to the BNT162b2 vaccine. No association with the ChAdOx1 vaccine was found after the second dose. Association with only the BNT162b2 vaccine was observed after the third dose. The risk for myocarditis was also higher in the 1 to 28 days following a positive SARS-CoV-2 test.
An increased risk of myocarditis was observed in men less than 40 years of age on days 1-28 following the first dose of mRNA-1273 and BNT162b2 vaccines, second dose of ChAdOx1, mRNA-1273, and BNT162b2 vaccines, third dose of BNT162b2 vaccine, and a SARS-CoV-2 positive test. In females, an increased risk of myocarditis was observed in 1-28 days following the second dose of the mRNA-1273 vaccine only. In the case of older women, no association between myocarditis and vaccination was observed while in older men the risk of myocarditis increased after the third dose of BNT162b2 vaccine and a positive SARS-CoV-2 test.
An estimate of the number of excess myocarditis events per million persons in the 1-28 days following exposure showed there would be an additional 1 and 2 myocarditis events per million exposed following the first dose of the ChAdOx1 and BNT162b2 vaccines, respectively. Approximately 2 and 36 myocarditis events could be expected after the second dose of BNT162b2 and mRNA-1273 vaccines, respectively, while an additional 2 myocarditis events per million persons could be expected after the third dose of BNT162b2. Following a positive test additional 30 myocarditis events per million could be expected.
An additional 3 and 12 myocarditis events per million in the 1-28 days were estimated in males less than 40 years of age following the first dose of BNT162b2 and mRNA-1273 vaccines respectively. An additional 14,12 and 101 myocarditis events could be estimated after the second dose of ChAdOx1, BNT162b2, and mRNA-1273 vaccines respectively, and an additional 13 events following the third dose of BNT162b2 vaccine. An additional 7 myocarditis events could be expected after a positive SARS-CoV-2 test. For older males, 3 and 73 events could be estimated following a third dose of BNT162b2 and a positive SARS-CoV-2 test respectively.
For females, less than 40 years, an additional 8 and 7 myocarditis events could be expected following the second dose of mRNA-1273 vaccine and a positive SARS-CoV-2 test, respectively. For older females, an additional 39 events per million could be expected following a positive SARS-CoV-2 test.
Therefore, the current study shows that the risk of death or hospitalization from myocarditis is higher following the first and second doses of vaccination. In contrast, the risk is significantly lower following the third vaccination dose. Furthermore, compared to adenovirus vaccines, mRNA vaccines had a higher risk. Additionally, the study indicated that myocarditis risk was higher in males under 40 years of age than females of the same age group.
