An antigenic map generated by Viroscience Department, Erasmus Medical Center, Rotterdam has depicted that all the Omicron subvariants were positioned farther away from the pre-Omicron subvariants, with one antigenic unit reflecting a two-fold reduction in neutralization titers. Specifically, only BA.5 and BA.2, being homologous variants, held antigenic positions within one antigenic unit, whereas the remaining Omicron subvariants held antigenic positions 2.3 to seven antigenic units farther from each other.
Further, the study data revealed that Omicron BA.5 antiserum samples neutralized BA.2 and BQ.1.1 substantially but not Omicron BM.1.1.1. Strikingly, none of the serum samples effectively neutralized Omicron XBB.1. In both two-dimensional (2D) and three-dimensional (3D) maps, Omicron XBB.1, BM.1.1.1, and BQ.1.1 were the farthest from all preceding variants, with no marked improvement with the higher number of dimensions.
Quite simply it's bad news even for Varaint Specific vaccines. XBB.1 lineage has an exceptionally robust antibody evasion activity. Another research done in Europe showed that even with four vaccines the situation is still the same. XBB.1 is not neutralised by antibodies generated against *even the most recent version* of Omicron, BA.5.
Neither Infection Immunity nor Vaccine Immunity works with XBB.1 lineage.
Further, the study data revealed that Omicron BA.5 antiserum samples neutralized BA.2 and BQ.1.1 substantially but not Omicron BM.1.1.1. Strikingly, none of the serum samples effectively neutralized Omicron XBB.1. In both two-dimensional (2D) and three-dimensional (3D) maps, Omicron XBB.1, BM.1.1.1, and BQ.1.1 were the farthest from all preceding variants, with no marked improvement with the higher number of dimensions.
Quite simply it's bad news even for Varaint Specific vaccines. XBB.1 lineage has an exceptionally robust antibody evasion activity. Another research done in Europe showed that even with four vaccines the situation is still the same. XBB.1 is not neutralised by antibodies generated against *even the most recent version* of Omicron, BA.5.
Neither Infection Immunity nor Vaccine Immunity works with XBB.1 lineage.
