වැක්සීන් ප්‍රශ්න?

jhnnwp

Well-known member
  • Jan 6, 2012
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    ඇයි මේ vaccine single dose එකකින් ආවෙ නැත්තේ?
    එකපාරින් වැඩේ ඉවර නොකර මොකද්ද මෙහෙම දෙන එකේ බලාපොරොත්තුව?
    testing කරන්නෙ ටික ටික ද?
     
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    fdk

    Well-known member
  • Sep 16, 2011
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    ඇයි මේ vaccine single dose එකකින් ආවෙ නැත්තේ?
    එකපාරින් වැඩේ ඉවර නොකර මොකද්ද මෙහෙම දෙන එකේ බලාපොරොත්තුව?
    testing කරන්නෙ ටික ටික ද?
    Profit maximisation
     

    imhotep

    Well-known member
  • Mar 29, 2017
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    This is mainly because a single dose does not elicit the immune response required to beat the infection. There's a boost effect from our immune system with the second dose. Basically, the first dose creates an immune response, while the second dose is a booster that strengthens your immunity to the virus. That's why it's called prime and boost. This comes in two forms, Homologous & Heterologous - in the first form the same vaccine is used (eg AZ, Pfizer) and the second two vaccines are used (Russsian Sputnik V ).
    Generally Heterologous method is more effective as it avoids any possible interference due to priming from the first.
    That's the reason why Sputnik has high efficacy and why I always advocated for mixing of vaccines. With two different vaccines the outcome could be much better. Of course you need to test and find out.

    Also note that there are some Covid vaccines which are single dose. The J&J is single dose. Sputnik Light is another. Also there are single dose vaccines under trial. The Australian DNA vaccine developed by the University of Sydney is single dose and protects against some variants too.

    Additionally, note that there are many common multi-dose vaccine regimes. eg MMR, Hep A, Hep B, Shingles.....etc. It's not an uncommon practice.

    So it's not marketing alone for maximising the profits, there are other reasons behind it. Don't believe Fakebook. :P
     

    sam_sajith

    Well-known member
  • May 25, 2009
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    This is mainly because a single dose does not elicit the immune response required to beat the infection. There's a boost effect from our immune system with the second dose. Basically, the first dose creates an immune response, while the second dose is a booster that strengthens your immunity to the virus. That's why it's called prime and boost. This comes in two forms, Homologous & Heterologous - in the first form the same vaccine is used (eg AZ, Pfizer) and the second two vaccines are used (Russsian Sputnik V ).
    Generally Heterologous method is more effective as it avoids any possible interference due to priming from the first.
    That's the reason why Sputnik has high efficacy and why I always advocated for mixing of vaccines. With two different vaccines the outcome could be much better. Of course you need to test and find out.

    Also note that there are some Covid vaccines which are single dose. The J&J is single dose. Sputnik Light is another. Also there are single dose vaccines under trial. The Australian DNA vaccine developed by the University of Sydney is single dose and protects against some variants too.

    Additionally, note that there are many common multi-dose vaccine regimes. eg MMR, Hep A, Hep B, Shingles.....etc. It's not an uncommon practice.

    So it's not marketing alone for maximising the profits, there are other reasons behind it. Don't believe Fakebook. :P
    I like the way you elaborate , thanks
     
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    niranga1989

    Well-known member
  • Jan 29, 2021
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    Single dose vaccine tiyei neda... american ewa

    This is mainly because a single dose does not elicit the immune response required to beat the infection. There's a boost effect from our immune system with the second dose. Basically, the first dose creates an immune response, while the second dose is a booster that strengthens your immunity to the virus. That's why it's called prime and boost. This comes in two forms, Homologous & Heterologous - in the first form the same vaccine is used (eg AZ, Pfizer) and the second two vaccines are used (Russsian Sputnik V ).
    Generally Heterologous method is more effective as it avoids any possible interference due to priming from the first.
    That's the reason why Sputnik has high efficacy and why I always advocated for mixing of vaccines. With two different vaccines the outcome could be much better. Of course you need to test and find out.

    Also note that there are some Covid vaccines which are single dose. The J&J is single dose. Sputnik Light is another. Also there are single dose vaccines under trial. The Australian DNA vaccine developed by the University of Sydney is single dose and protects against some variants too.

    Additionally, note that there are many common multi-dose vaccine regimes. eg MMR, Hep A, Hep B, Shingles.....etc. It's not an uncommon practice.

    So it's not marketing alone for maximising the profits, there are other reasons behind it. Don't believe Fakebook. :P
    me yaka wishwakosyak
    ------ Post added on Aug 10, 2021 at 7:51 PM