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Important Warnings
Fluoroquinolones, including norfloxacin, carry strong clinical warnings (such as Black Box warnings in the US) due to the risk of severe, potentially irreversible adverse reactions:
Tendon Rupture: Increased risk of tendonitis and tendon rupture, most commonly affecting the Achilles tendon. The risk is significantly higher in people over 60, those taking corticosteroid drugs, and kidney, heart, or lung transplant recipients.
Nerve Damage: Can cause peripheral neuropathy, presenting as pain, burning, tingling, or weakness in the arms or legs.
Central Nervous System Effects: May trigger seizures, tremors, anxiety, confusion, or hallucinations.
Myasthenia Gravis: Can severely exacerbate muscle weakness in people diagnosed with this condition.