there is. you just have to be careful. most of the worms are activated by autoruns in pen drives. so we just have to disable autoruning.
assuming you are using windows XP,
1) Goto start -> Run -> Type gpedit.msc
2) This will load the group policy editor
3) Goto Administrative Templates -> System -> Find "Turn off Autoplay"
4) Then
Enable it for all drives (choose it from the drop down box)
this should disable autoruns.
when you open your pen dirive always make sure that you press and HOLD the SHIFT key before double clicking on the pen drive.
or just right click and choose OPEN.
and when you see autorun.infs and other virus/worm like .exes always delete them.
and use an antivirus software and always scan your pen before opening it.
hope this helps.
