The Dire Wolf Is Back from Extinction

Stimulus mind

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    imhotep

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    If this is true, it would be great news and good chance in dextincting some valuable species. Such as the Australian tiger, passenger pigeon, nightingale bird, dodo bird, etc.
    Colossal Biosceinces did it. Previously I did mention about Colossal in a thread related to Mammoth. The Dire Wolf genome was recovered from a 13,000-year-old tooth found in Sheridan Pit, Ohio, the other a 72,000-year-old ear bone unearthed in American Falls, Idaho.
     

    Asmodeus

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  • Feb 6, 2023
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    Ursa Major
    Colossal Biosceinces did it. Previously I did mention about Colossal in a thread related to Mammoth. The Dire Wolf genome was recovered from a 13,000-year-old tooth found in Sheridan Pit, Ohio, the other a 72,000-year-old ear bone unearthed in American Falls, Idaho.
    I thought the DNA disintegrate with time. how did they manage to complete the genome?
     

    imhotep

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    I thought the DNA disintegrate with time. how did they manage to complete the genome?
    Modern advances in technology allows half a million year old to be sequenced. I believe the oldest recovered is about 1 million year old.

    They just edited the grey wolf genome to mimic dire wolf genome as much as possible I think.

    Imagine the edits they could make to the human genome, they can mimic all the greatest athletes of all time and make a super human 😎
    Yes... They took a different approach.

    "Colossal’s dire wolf work took a less invasive approach, isolating cells not from a tissue sample of a donor gray wolf, but from its blood. The cells they selected are known as endothelial progenitor cells (EPCs), which form the lining of blood vessels. The scientists then rewrote the 14 key genes in the cell’s nucleus to match those of the dire wolf; no ancient dire wolf DNA was actually spliced into the gray wolf’s genome. The edited nucleus was then transferred into a denucleated ovum. The scientists produced 45 engineered ova, which were allowed to develop into embryos in the lab. Those embryos were inserted into the wombs of two surrogate hound mixes, chosen mostly for their overall health and, not insignificantly, their size, since they’d be giving birth to large pups. In each mother, one embryo took hold and proceeded to a full-term pregnancy. (No dogs experienced a miscarriage or stillbirth.) On Oct. 1, 2024, the surrogates birthed Romulus and Remus. A few months later, Colossal repeated the procedure with another clutch of embryos and another surrogate mother. On Jan. 30, 2025, that dog gave birth to Khaleesi."
    ------ Post added on Apr 8, 2025 at 5:35 PM
     

    dinuksha_asela

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    They just edited the grey wolf genome to mimic dire wolf genome as much as possible I think.

    Imagine the edits they could make to the human genome, they can mimic all the greatest athletes of all time and make a super human 😎
    It is said that the Chinese has pioneered this Tech. they've already created an enhanced Human Gnome it seems.. Saw a post.. ill post it if i found it again..
     
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    imhotep

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    Did Dire Wolves Just Come Back From Extinction? Here's The Truth.

    https://www.sciencealert.com/did-dire-wolves-just-come-back-from-extinction-heres-the-truth


    "It's a bit like the guy in the Chinese zoo who had dogs that he painted to be pandas. And everyone you know fell for that story."

    True... That's why some claim it is a designer Dog. :unsure: But Colossal published the methodology how they created this Dire Wolf and it wasn't a secret.
    Some scientists believe that the Dire Wolf was in fact an evolutionary lineage of an ancient dog. The resemblance between dire wolves and gray wolves is an example of convergent evolution.

    PS: Read Beth Shapiro's book "How to Clone a Mammoth," she basically says right at the start that cloning a mammoth will probably never happen. She then talks about other methods being tried and dives into the ethics and reasons behind de-extinction efforts.
    Note that the book is about a decade old.
     
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