ඔය පළවෙනි ඩෝස් එකට බං. මාසෙකින් දෙවනි එක දෙනවා. මට මාර්තු මුල
හරි නම් දෙවනි එක ගැහුවම ඉමියුනිලොජි රිඇක්ශන් වැඩි වෙන්න ඕනේ. දෙවනි එකත් ගැහුවම අප්ඩේට් එකක් දෙන්නම්.
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COVISHIELD VACCINE
- Thread starter Ridila™
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හරි නම් දෙවනි එක ගැහුවම ඉමියුනිලොජි රිඇක්ශන් වැඩි වෙන්න ඕනේ. දෙවනි එකත් ගැහුවම අප්ඩේට් එකක් දෙන්නම්.
ඩිම්පන්සියෙක්ගෙන් ගත්තු ඉන්ෆෙක්ටඩ් ඇඩිනෝවයිරස් එකකට කොවිඩ් spike protein කෑලි ටිකක් දාලා දෙන්නේ. මට උඹ ඇඩෙන්ඩට් නෙමෙයු මොක කිව්වත් අවුලක් නෑ මිත්රයා අවුරුදු 10 කට කලින් එද්දි එලකිරියට මට වයස 22 යි. ඒ කාලේට සාපෙක්ශව මේ වෙද්දි සෑහෙන mature.
ඒ නිසා උඹ ඕනේ දෙයක් කියාගනින්. Cheers...
ඔව් රජයේ රෝහල් වල ඕක කෙරෙනවා ඉස්සරහට. ඕක තමයි ප්ලෑන් එක.
------ Post added on Feb 4, 2021 at 7:53 AM
ඉන්නවා මචන්.
------ Post added on Feb 4, 2021 at 7:55 AM
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COVISHIELD කියලා දෙන්නේ අඩ පණ කරපු සජීවී කොවිඩ් වයිරස් එකේ කොටස් ( Live attenuated vaccine). ඒකත් පැපොල, සරම්ප, කම්බුල්ගාය , රුබෙල්ලා වගේ. ප්රතිශක්තිය අඩු නම් ඇඟේ වයිරස් එක ඇක්ටිව් වෙන්න පුලුවන්.
හොඳටම හොඳයි බං. දැන් වෝඩ් රවුන්ඩ් යන්න ඕනේ.
------ Post added on Feb 4, 2021 at 7:57 AM
The Oxford vaccine is an adenovirus vector vaccine. The adenovirus vector used has an inserted gene that encodes the full-length SARS-CoV-2 spike protein.
The idea to use an adenovirus as a vector to deliver the vaccine is simply because the virus can enter the human cells quite easily by attaching with the host receptors and then release their genome in to the human cells. So this particular vaccine, once inside the human cells will start producing the spike protein, because it's been modified to do so.
The produced spike protein then acts as an antigen to prime the body immune system to recognize SARS-CoV-2 if it infects the body at a later date.
But there's a small snag in the above scenario. There are several adenoviruses that affect us, and many people have adenovirus-specific antibodies that could bind and neutralize these vectors. So, when a person is given a viral-vector vaccine, as well as generating an immune response against the coronavirus’s spike protein, the immune system will also mount a response against the viral vector itself.
Hence the research scientists at Oxford used a clever approach. They used an adenovirus of chimpanzee origin that does not normally infect humans. Hence we would not likely have pre-existing antibodies to the adenovirus vector used. They also changed the adenovirus itself by the deletion of TWO genes. One of the genes deleted is the one regulating the virus replication - this makes sure that virus cannot create an infection in human cells, and the second deletion was to get the space to insert the gene that will code for the SARS-CoV-2 spike protein.
OTOH Gamelaya (Russian vaccine developer) used another approach. They used their already existing Ebola vaccine platform. They used used TWO different human adenovirus vectors – Ad26 and Ad5 (out of the 50 odd that affect humans) – for its two vaccine doses. This hybrid vaccine, with two different vectors for prime and booster vaccinations, is less likely to have one jab generate an immune response against the viral vector that then interferes with the other.
Don't get fooled by the crap on the Internet saying that mRNA or an adenovirus will alter your DNA. Total bull!@#$ and you will not turn into a Chimpanzee.
Our cell machinery does have extended capabilities, that goes beyond manufacturing of human proteins. What happens when we get invaded by a virus? The virus injects it's genetic material, resulting in pieces of mRNA encoding viral proteins being sent to our protein-making machinery. This enables the virus to assemble new viral particles and spread. But that doesn't alter your DNA. Otherwise everytime you fall sick, your DNA will get altered.
It's exactly the same with the vaccine.
As I have mentioned before several adenovirus based vaccines (HIV, Ebola, TB) and several mRNA vaccines (rabies, influenza, cytomegalovirus, and Zika) have been used on humans before. More than 300,000 Zika vaccines has been given in Congo alone.
The idea to use an adenovirus as a vector to deliver the vaccine is simply because the virus can enter the human cells quite easily by attaching with the host receptors and then release their genome in to the human cells. So this particular vaccine, once inside the human cells will start producing the spike protein, because it's been modified to do so.
The produced spike protein then acts as an antigen to prime the body immune system to recognize SARS-CoV-2 if it infects the body at a later date.
But there's a small snag in the above scenario. There are several adenoviruses that affect us, and many people have adenovirus-specific antibodies that could bind and neutralize these vectors. So, when a person is given a viral-vector vaccine, as well as generating an immune response against the coronavirus’s spike protein, the immune system will also mount a response against the viral vector itself.
Hence the research scientists at Oxford used a clever approach. They used an adenovirus of chimpanzee origin that does not normally infect humans. Hence we would not likely have pre-existing antibodies to the adenovirus vector used. They also changed the adenovirus itself by the deletion of TWO genes. One of the genes deleted is the one regulating the virus replication - this makes sure that virus cannot create an infection in human cells, and the second deletion was to get the space to insert the gene that will code for the SARS-CoV-2 spike protein.
OTOH Gamelaya (Russian vaccine developer) used another approach. They used their already existing Ebola vaccine platform. They used used TWO different human adenovirus vectors – Ad26 and Ad5 (out of the 50 odd that affect humans) – for its two vaccine doses. This hybrid vaccine, with two different vectors for prime and booster vaccinations, is less likely to have one jab generate an immune response against the viral vector that then interferes with the other.
Don't get fooled by the crap on the Internet saying that mRNA or an adenovirus will alter your DNA. Total bull!@#$ and you will not turn into a Chimpanzee.
Our cell machinery does have extended capabilities, that goes beyond manufacturing of human proteins. What happens when we get invaded by a virus? The virus injects it's genetic material, resulting in pieces of mRNA encoding viral proteins being sent to our protein-making machinery. This enables the virus to assemble new viral particles and spread. But that doesn't alter your DNA. Otherwise everytime you fall sick, your DNA will get altered.
It's exactly the same with the vaccine.
As I have mentioned before several adenovirus based vaccines (HIV, Ebola, TB) and several mRNA vaccines (rabies, influenza, cytomegalovirus, and Zika) have been used on humans before. More than 300,000 Zika vaccines has been given in Congo alone.
මගේ යාලු ගර්ල් කෙනෙකුගෙ පුතාට හැදුන බන්. පව් බන් පොඩි කොල්ල. ගොදට 100Km බයිසිකල් පැදපු කොල්ල.
machan asthma thiyana aya ganna inhaler nisa ayalata gahana vaccine eka hariyata wada karanne na kiyala samahara doc la kiyanawa eka atha da ?? eka ehema nam me vaccine ekata eka balapai neada ??
සෞක්යය සහ හමුදා ඉවර උනාට පස්සෙ ( ගොඩක් වෙලාවට 12 වෙද්දි ඉවරයි) vaccine ලැබීම අනුව රජය රෝහල් වලින් වැඩසටහන් ක්රියාත්මක කරන්න තමයි මචං සැලසුම් කරලා තියෙන්නෙ.
Lung fibrosis උනාද?මගේ යාලු ගර්ල් කෙනෙකුගෙ පුතාට හැදුන බන්. පව් බන් පොඩි කොල්ල. ගොදට 100Km බයිසිකල් පැදපු කොල්ල.
------ Post added on Feb 4, 2021 at 5:49 PM
ඕක බොරු කතාවල් බං.ඉන්හේලර්ස් වල දුඹුරු පාට කලර් කෝඩින් ඉන්හේලර්ස් දීර්ඝ කාලීනව ගන්න ඕනේ ඇඳුම පාලනය කරන්න නම්. නමුත් ඒක ඉන්හේලර් විදිහට දෙන්නෙ ස්වසන පද්දතියට විතරක් ලිමිට්වෙන්නයි.
ඉන්හේලර් ගත්තට අවුලක් නෑ.
ට සිරි උනා කියන්නකෝ චාමිකා... කොහොමද ඉතින් දැන් බබාලා ඉන්නවද?Ridilata sahenna ridila neda vaccine eka gahala..
------ Post added on Feb 4, 2021 at 5:52 PM
ආහ් මලයා
------ Post added on Feb 4, 2021 at 5:53 PM
මමත් වැක්සින් එක ගත්ත . ලොකු අමාරුවක් ආවෙ නම් නැ. පොඩ්ඩක් ඇග සීතල කලා විතරයි .
