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WHO says untreated pneumonic plague can become fatal within roughly 18–24 hours after symptoms begin, but antibiotics plus supportive care can cure it when treatment is started early. CDC lists several effective antibiotic options for pneumonic plague, and people with significant exposure can also receive preventive antibiotics.
For pneumonic plague caused by Yersinia pestis, the main effective antibiotics include ciprofloxacin, levofloxacin, moxifloxacin, gentamicin, and streptomycin. CDC considers these first-line options; doxycycline is also used in some situations, and other alternatives exist.
