There were many. The above is a The Dodge Tomahawk is potentially the most famous car-engined motorcycle ever. Powered by the 8.3-litre V10 from a 2003 SRT Viper, the Tomahawk produces 510bhp and 535lb ft of torque. This was never sold as a public model.
There was a British one built on the same engine. The Millyard Viper V10.
PS: Just recollected a quote from Arthur Hailey's "
Wheels" about a car... -
It's a motorbike on four wheels, and a poor one at that.