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මගේ අම්මට පිළිකාවක් හැදිලා... පින් සිද්ද වෙයි........
- Thread starter dinuka rukshan
- Start date
https://www.ndtv.com/world-news/fir...ishes-for-every-patient-in-drug-trial-3044922
Meka poddak alert eke inna cancer patientslata digatama denna gaththoth rata gihin hari ammata treatments krganna.
Ammata ikman suwa pathanawa
Meka poddak alert eke inna cancer patientslata digatama denna gaththoth rata gihin hari ammata treatments krganna.
Ammata ikman suwa pathanawa
ටහුඩුhttps://www.ndtv.com/world-news/fir...ishes-for-every-patient-in-drug-trial-3044922
Meka poddak alert eke inna cancer patientslata digatama denna gaththoth rata gihin hari ammata treatments krganna.
Ammata ikman suwa pathanawa
@imhotep bro me kiyane me drug eka gena neda https://en.wikipedia.org/wiki/Dostarlimab . meka danata gana thiyena ekakmada me cancer walata use karala thiyene.https://www.ndtv.com/world-news/fir...ishes-for-every-patient-in-drug-trial-3044922
Meka poddak alert eke inna cancer patientslata digatama denna gaththoth rata gihin hari ammata treatments krganna.
Ammata ikman suwa pathanawa
@dinuka rukshan machan me drug eka online penanawa. ammawa penana doctorgen ahala meka okda balala aye update ekak dapan. beheth tika gena gana widiyak ita pase balamu.
https://thesocialmedwork.com/jemperli-dostarlimab
------ Post added on Jun 9, 2022 at 3:59 AM
Last edited:
බයවෙන්න එපා මචං. හැමදේම බෙහෙත් වලින්ම තීරණය වෙන්නෙත් නෑනෙ. කර්ම ශක්තිය, කෑම බීම, වටපිටාව වගේ තව කීයක් ජාති තියෙනවද.
ශක්තිමත්ව ඉන්න. ඔයාගෙ අම්මට ඉක්මන් සුවය ලැබේවා කියලා ප්රාර්ථනා කරනවා. වැදගත් දෙයක් දැනගන්න ලැබුනොත් අනිවා කියන්නම්.
ශක්තිමත්ව ඉන්න. ඔයාගෙ අම්මට ඉක්මන් සුවය ලැබේවා කියලා ප්රාර්ථනා කරනවා. වැදගත් දෙයක් දැනගන්න ලැබුනොත් අනිවා කියන්නම්.
Yes.. Briefly this drug belongs to a class called "Checkpoint Inhibitors". Cancer cells usually places a shield around them that blocks T-cells in our immune system, so the T-cells cannot attack them. A Checkpoint Inhibitor removes this shield, and thus the cancer cell gets exposed and thus our immune system destroys them.
Immune Checkpoint Inhibitor therapy isn't new... A decade old. The first FDA approved drug was in 2011, Ipilimumab, the first antibody blocking an immune checkpoint (CTLA4) inhibitor. There are several others eg: Pembrolizumab (Keytruda®) and Nivolumab (Opdivo®), Atezolizumab (Tecentriq®) as well.
Jemperli (Dostarlimab) was invented in 2014. It's a Programmed Death Receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2. ( A Ligand is molecule that irreversibly binds to a receiving protein molecule, otherwise known as a receptor)
It was approved for patients who has a biomarker called dMMR. this biomarker is commonly associated with endometrial, colorectal and other gastrointestinal cancers... but also it may be in other solid tumors too.
In normal cells MMR (MisMatch Repair) process corrects DNA replication errors using enzymes. basically it checks the integrity of the DNA strand and fixes any mistakes. For some people who are dMMR (deficient MMR) these enzymes do not function as normal, thus the errors are not corrected leading towards a cancer cell.
Dostarlimab can be used in combination with Niraparib, Carboplatin–Paclitaxel, sometimes with Bevacizumab in advanced cancers. If you check the US databases you could probably find several thousands of cancer trials using these drugs. Also wonder how long and the associated costs it takes to test, develop these drugs.
(These guys aren't as advanced as our local druids who mix thel & pani concoctions
)Monoclonal antibodies aren't cheap. Dostarlimab was given to the test patients every three to six months at a cost of $11,000 each dose. If the drug proves itself many governments will subsidise cost to the patients. Also the Indians will be able to make these at a much lower cost.
Whatever it is, it's good news.
PS: Wish his mother a rapid recovery. With all sorts of medicines and surgical supplies in short supply the picture isn't good at all, for everyone.
මාත් ඔය ගැන ත්රෙඩ් එකක් දැම්මා.Yes.. Briefly this drug belongs to a class called "Checkpoint Inhibitors". Cancer cells usually places a shield around them that blocks T-cells in our immune system, so the T-cells cannot attack them. A Checkpoint Inhibitor removes this shield, and thus the cancer cell gets exposed and thus our immune system destroys them.
Immune Checkpoint Inhibitor therapy isn't new... A decade old. The first FDA approved drug was in 2011, Ipilimumab, the first antibody blocking an immune checkpoint (CTLA4) inhibitor. There are several others eg: Pembrolizumab (Keytruda®) and Nivolumab (Opdivo®), Atezolizumab (Tecentriq®) as well.
Jemperli (Dostarlimab) was invented in 2014. It's a Programmed Death Receptor-1 (PD-1)-blocking antibody that binds to the PD-1 receptor and blocks its interaction with the PD-1 ligands PD-L1 and PD-L2. ( A Ligand is molecule that irreversibly binds to a receiving protein molecule, otherwise known as a receptor)
It was approved for patients who has a biomarker called dMMR. this biomarker is commonly associated with endometrial, colorectal and other gastrointestinal cancers... but also it may be in other solid tumors too.
In normal cells MMR (MisMatch Repair) process corrects DNA replication errors using enzymes. basically it checks the integrity of the DNA strand and fixes any mistakes. For some people who are dMMR (deficient MMR) these enzymes do not function as normal, thus the errors are not corrected leading towards a cancer cell.
Dostarlimab can be used in combination with Niraparib, Carboplatin–Paclitaxel, sometimes with Bevacizumab in advanced cancers. If you check the US databases you could probably find several thousands of cancer trials using these drugs. Also wonder how long and the associated costs it takes to test, develop these drugs.
(These guys aren't as advanced as our local druids who mix thel & pani concoctions
Monoclonal antibodies aren't cheap. Dostarlimab was given to the test patients every three to six months at a cost of $11,000 each dose. If the drug proves itself many governments will subsidise cost to the patients. Also the Indians will be able to make these at a much lower cost.
Whatever it is, it's good news.
PS: Wish his mother a rapid recovery. With all sorts of medicines and surgical supplies in short supply the picture isn't good at all, for everyone.
View attachment 173831
ගුද මාර්ගයේ පිළිකා සුව කරන නව ඖෂධයක් 
Machan matath oya feeling ekama tibba mage thathath cancer ekak haduna , mata kenek kiywa India wala thanak thiyanwa kiyala , poddak online balapan machoo, ikman suwaya ammata. GOD bless!!!
ස්ටීව් ජොබ්ස්ටත් තිබ්බ.ඒ වුනාට ඒක වෙනස් ඵකක්..ඉක්මන් සුව.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924574/#:~:text=Jobs was diagnosed with a,often rapidly fatal pancreatic adenocarcinoma.
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