A growing collection of evidence supports that creatine supplementation may improve health status as individuals age [
41,
43,
44,
45,
195]. In this regard, creatine supplementation has been reported to help lower cholesterol and triglyceride levels [
67,
196]; reduce fat accumulation in the liver [
197]; reduce homocysteine levels [
198]; serve as an antioxidant [
199,
200,
201,
202]; enhance glycemic control [
132,
203,
204,
205]; slow tumor growth in some types of cancers [
32,
198,
206,
207]; increase strength and/or muscle mass [
37,
41,
44,
45,
82,
208,
209,
210,
211,
212]; minimize bone loss [
211,
212]; improve functional capacity in patients with knee osteoarthritis [
213] and fibromyalgia [
214]; positively influence cognitive function [
43,
83,
195]; and in some instances, serve as an anti-depressant [
215,
216,
217].